| Improved stenosis geometry by quantitative coronary arteriography after vigorous risk factor modification. | |
| | |
MedLine Citation:
|
PMID: 1550011 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This study is a randomized, controlled, blinded, arteriographic trial to determine the effects of a low-cholesterol, low-fat, vegetarian diet, stress management and moderate aerobic exercise on geometric dimensions, shape and fluid dynamic characteristics of coronary artery stenoses in humans. Complex changes of different primary stenosis dimensions in opposite directions or to different degrees cause stenosis shape change with profound effects on fluid dynamic severity, not accounted for by simple percent narrowing. Accordingly, all stenosis dimensions were analyzed, including proximal, minimal, distal diameter, integrated length, exit angles and exit effects, determining stenosis shape and a single integrated measure of stenosis severity, stenosis flow reserve reflecting functional severity. In the control group, complex shape change and a stenosis-molding characteristic of statistically significant progressing severity occurred with worsening of stenosis flow reserve. In the treated group, complex shape change and stenosis molding characteristic of significant regressing severity was observed with improved stenosis flow reserve, thereby documenting the multidimensional characteristics of regressing coronary artery disease in humans. |
| | |
Authors:
|
K L Gould; D Ornish; R Kirkeeide; S Brown; Y Stuart; M Buchi; J Billings; W Armstrong; T Ports; L Scherwitz |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The American journal of cardiology Volume: 69 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1992 Apr |
Date Detail:
|
Created Date: 1992-04-17 Completed Date: 1992-04-17 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 845-53 Citation Subset: AIM; IM |
Affiliation:
|
University of Texas Medical School, Division of Cardiology, Houston 77225. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Analysis of Variance Coronary Angiography Coronary Disease / radiography*, therapy* Double-Blind Method Female Humans Male Middle Aged Risk Factors Severity of Illness Index |
| Grant Support | |
ID/Acronym/Agency:
|
HL 26885/HL/NHLBI NIH HHS; HL 42554/HL/NHLBI NIH HHS; R01 HL 26862/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of chronic congestive heart failure on 24-hour blood pressure and heart rate patterns: a hem...
Next Document: Prediction by postexercise fluoro-18 deoxyglucose positron emission tomography of improvement in exe...