Document Detail


Improved selection of patients for reoperation for medullary thyroid cancer by imaging with radiolabeled anticarcinoembryonic antigen antibodies.
MedLine Citation:
PMID:  9426433     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: This study examined the utility of using radiolabeled anticarcinoembryonic antigen (CEA) monoclonal antibodies (MAbs) as a noninvasive imaging method to aid in the selection of patients for reoperation after operation for medullary thyroid carcinoma (MTC). METHODS: Sixteen patients with persistent or recurrent hypercalcitoninemia since operation or MTC, but had negative or equivocal conventional imaging study results, were given 99mTc-, 123I-, or 131I-labeled NP-4 or MN-14 anti-CEA MAbs. Scintigraphic images were then performed to determine detection of tumor lesions. RESULTS: The MAb scans were positive in 13 (81%) of the 16 patients studied. However, in only three of 13 patients was disease confined to the cervical or mediastinal nodes. In 10 patients, disease was additionally or solely found in distant organs such as liver (five patients), bone (four patients), and periaortic nodes (one patient). On the basis of our studies, only three of the 13 patients with positive scans would benefit from repeat neck exploration, another three would possibly benefit from neck or mediastinal exploration and hepatic resection, and the remaining seven patients would not benefit from any reoperation with curative intent. CONCLUSIONS: MTC imaging with anti-CEA MAbs could be very useful in determining the ideal candidates for repeat neck exploration.
Authors:
M Juweid; R M Sharkey; L C Swayne; D M Goldenberg
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Surgery     Volume:  122     ISSN:  0039-6060     ISO Abbreviation:  Surgery     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-01-22     Completed Date:  1998-01-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1156-65     Citation Subset:  AIM; IM    
Affiliation:
Garden State Cancer Center, Belleville, NJ 07109, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Animals
Antibodies, Monoclonal / adverse effects,  diagnostic use*,  immunology
Carcinoembryonic Antigen / immunology*
Carcinoma, Medullary / radionuclide imaging,  surgery*
Female
Humans
Male
Mice
Middle Aged
Radioimmunodetection*
Reoperation
Thyroid Neoplasms / radionuclide imaging,  surgery*
Tomography, X-Ray Computed
Grant Support
ID/Acronym/Agency:
CA 66906-01/CA/NCI NIH HHS; CA39841/CA/NCI NIH HHS; FD-R-001190-01/FD/FDA HHS
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Carcinoembryonic Antigen

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