| Improved selection of patients for reoperation for medullary thyroid cancer by imaging with radiolabeled anticarcinoembryonic antigen antibodies. | |
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MedLine Citation:
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PMID: 9426433 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: This study examined the utility of using radiolabeled anticarcinoembryonic antigen (CEA) monoclonal antibodies (MAbs) as a noninvasive imaging method to aid in the selection of patients for reoperation after operation for medullary thyroid carcinoma (MTC). METHODS: Sixteen patients with persistent or recurrent hypercalcitoninemia since operation or MTC, but had negative or equivocal conventional imaging study results, were given 99mTc-, 123I-, or 131I-labeled NP-4 or MN-14 anti-CEA MAbs. Scintigraphic images were then performed to determine detection of tumor lesions. RESULTS: The MAb scans were positive in 13 (81%) of the 16 patients studied. However, in only three of 13 patients was disease confined to the cervical or mediastinal nodes. In 10 patients, disease was additionally or solely found in distant organs such as liver (five patients), bone (four patients), and periaortic nodes (one patient). On the basis of our studies, only three of the 13 patients with positive scans would benefit from repeat neck exploration, another three would possibly benefit from neck or mediastinal exploration and hepatic resection, and the remaining seven patients would not benefit from any reoperation with curative intent. CONCLUSIONS: MTC imaging with anti-CEA MAbs could be very useful in determining the ideal candidates for repeat neck exploration. |
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Authors:
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M Juweid; R M Sharkey; L C Swayne; D M Goldenberg |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Surgery Volume: 122 ISSN: 0039-6060 ISO Abbreviation: Surgery Publication Date: 1997 Dec |
Date Detail:
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Created Date: 1998-01-22 Completed Date: 1998-01-22 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0417347 Medline TA: Surgery Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1156-65 Citation Subset: AIM; IM |
Affiliation:
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Garden State Cancer Center, Belleville, NJ 07109, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Animals Antibodies, Monoclonal / adverse effects, diagnostic use*, immunology Carcinoembryonic Antigen / immunology* Carcinoma, Medullary / radionuclide imaging, surgery* Female Humans Male Mice Middle Aged Radioimmunodetection* Reoperation Thyroid Neoplasms / radionuclide imaging, surgery* Tomography, X-Ray Computed |
| Grant Support | |
ID/Acronym/Agency:
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CA 66906-01/CA/NCI NIH HHS; CA39841/CA/NCI NIH HHS; FD-R-001190-01/FD/FDA HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Carcinoembryonic Antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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