Document Detail


Improved right ventricular function and reduced pulmonary vascular resistance during prazosin therapy of congestive heart failure.
MedLine Citation:
PMID:  6113759     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although the effect of systemic vasodilator therapy on left ventricular function in congestive heart failure has been extensively evaluated, little is known about its effect on pulmonary vascular resistance and right ventricular function. Since pulmonary vascular resistance is mediated in part by alpha-adrenergic receptors, we studied the effects of the alpha-adrenergic antagonist prazosin on right ventricular function as determined by a radionuclide ventriculographic technique which assessed right and left ventricular ejection fractions simultaneously. In 11 patients treated for two months with prazosin, right ventricular ejection fraction increased from 0.28 +/- 0.04 to 0.44 +/- 0.07 (p less than 0.01). In 10 patients who received a single dose of prazosin 48 hours after withdrawal of prior prazosin therapy, right ventricular ejection fraction increased from 0.29 to 0.05 to 0.38 +/- 0.06 (p less than 0.02). In nine patients who received a single dose of prazosin during right sided heart catheterization, pulmonary vascular resistance decreased from 358 +/- 70 to 236 +/- 60 dyne-sec-cm -5 (p less than 0.01). These studies suggest that prazosin has beneficial effects on right ventricular function both immediately and long-term in patients with severe congestive heart failure. Although the mechanism of this effect is not known, possibilities include a direct effect of prazosin on the pulmonary vasculature, a secondary reduction in right ventricular afterload due to improved left ventricular performance and a withdrawal of reflex-mediated pulmonary vasoconstriction due to improved left ventricular performance.
Authors:
W S Colucci; B L Holman; J Wynne; B Carabello; R Malacoff; W Grossman; E Braunwald
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of medicine     Volume:  71     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1981-08-27     Completed Date:  1981-08-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  75-80     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Antagonists / therapeutic use*
Female
Heart Failure / drug therapy*
Heart Ventricles / drug effects
Humans
Lung / blood supply
Male
Middle Aged
Prazosin / therapeutic use*
Quinazolines / therapeutic use*
Vascular Resistance / drug effects
Grant Support
ID/Acronym/Agency:
4-M01-RR00888/RR/NCRR NIH HHS; HL-07049/HL/NHLBI NIH HHS; HL-24241/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Quinazolines; 19216-56-9/Prazosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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