Document Detail

Improved prognosis after coronary thrombolysis with urokinase in acute myocardial infarction.
MedLine Citation:
PMID:  3444037     Owner:  NLM     Status:  MEDLINE    
The effectiveness of coronary thrombolysis with urokinase (UK) on short- and long-term outcome after acute myocardial infarction was studied by comparison of 120 patients treated with UK and 124 with conventional therapy followed up for a period of 20 months. UK was administered to patients within 6 hours of the onset of chest pain, by the intracoronary route (20,000 U/min, at a mean dose of 698,000 U) in 46 patients, intravenously (960,000 to 1,920,000 U in 15 or 30 min, at a mean dose of 1,293,000 U) in 56 patients and by the combined route (at a mean dose of 2,333,000 U) in 18 patients. Complete occlusion or 99% stenosis with severe delay of the contrast medium was found in 72.5% and recanalization by UK was achieved in 68.0%. Cumulative mortality rate was significantly reduced in the UK group (9.2% vs. 29.0%). Cardiac death from recurrent MI was also significantly reduced (2.5% vs. 10.5%). The reduction in mortality rate was demonstrated even in older patients as well as in those cases graded as severe according to the Killip and Forrester classifications. Thus, it is concluded that coronary thrombolysis with UK therapy improves the prognosis of acute myocardial infarction.
R Katori; K Ishikawa; K Kanamasa; M Morishita; M Ohno; I Ogawa; H Namikawa; A Okayama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese heart journal     Volume:  28     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1988-05-06     Completed Date:  1988-05-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  863-72     Citation Subset:  IM    
First Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan.
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MeSH Terms
Coronary Vessels
Follow-Up Studies
Infusions, Intra-Arterial
Infusions, Intravenous
Injections, Intra-Arterial
Middle Aged
Myocardial Infarction / drug therapy*,  mortality
Urokinase-Type Plasminogen Activator / administration & dosage,  therapeutic use*
Reg. No./Substance:
EC Plasminogen Activator

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