| Improved prognosis after coronary thrombolysis with urokinase in acute myocardial infarction. | |
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MedLine Citation:
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PMID: 3444037 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effectiveness of coronary thrombolysis with urokinase (UK) on short- and long-term outcome after acute myocardial infarction was studied by comparison of 120 patients treated with UK and 124 with conventional therapy followed up for a period of 20 months. UK was administered to patients within 6 hours of the onset of chest pain, by the intracoronary route (20,000 U/min, at a mean dose of 698,000 U) in 46 patients, intravenously (960,000 to 1,920,000 U in 15 or 30 min, at a mean dose of 1,293,000 U) in 56 patients and by the combined route (at a mean dose of 2,333,000 U) in 18 patients. Complete occlusion or 99% stenosis with severe delay of the contrast medium was found in 72.5% and recanalization by UK was achieved in 68.0%. Cumulative mortality rate was significantly reduced in the UK group (9.2% vs. 29.0%). Cardiac death from recurrent MI was also significantly reduced (2.5% vs. 10.5%). The reduction in mortality rate was demonstrated even in older patients as well as in those cases graded as severe according to the Killip and Forrester classifications. Thus, it is concluded that coronary thrombolysis with UK therapy improves the prognosis of acute myocardial infarction. |
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Authors:
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R Katori; K Ishikawa; K Kanamasa; M Morishita; M Ohno; I Ogawa; H Namikawa; A Okayama |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Japanese heart journal Volume: 28 ISSN: 0021-4868 ISO Abbreviation: Jpn Heart J Publication Date: 1987 Nov |
Date Detail:
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Created Date: 1988-05-06 Completed Date: 1988-05-06 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0401175 Medline TA: Jpn Heart J Country: JAPAN |
Other Details:
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Languages: eng Pagination: 863-72 Citation Subset: IM |
Affiliation:
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First Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Coronary Vessels Female Follow-Up Studies Humans Infusions, Intra-Arterial Infusions, Intravenous Injections, Intra-Arterial Male Middle Aged Myocardial Infarction / drug therapy*, mortality Prognosis Recurrence Urokinase-Type Plasminogen Activator / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.73/Urokinase-Type Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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