Document Detail

Improved procedure for lecithin/sphingomyelin ratio in amniotic fluid reduces false predictions of lung immaturity.
MedLine Citation:
PMID:  7055955     Owner:  NLM     Status:  MEDLINE    
Many laboratories have found that their procedure for determining lecithin/sphingomyelin (L/S)ratios gives an unacceptably high proportion of false predictions of fetal lung immaturity. We investigated each step in the procedure, in an attempt to improve the clinical performance of the test and to make the method more amenable to standardization between laboratories. L/S ratios were determined by the new procedure in amniotic fluid from 147 pregnancies, collected within two days of delivery of the infant. Four cases had an L/S ratio less than 2; all developed hyaline membrane disease. No other cases of hyaline membrane disease were encountered in this study. For 106 of these pregnancies, the L/S ratio was also determined by the procedure previously in use. This predicted lung immaturity for 16 infants, only four of whom developed hyaline membrane disease. All 12 cases incorrectly predicted as immature by the old procedure were correctly classified by the new procedure.
L M Brown; C G Duck-Chong; W J Hensley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical chemistry     Volume:  28     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  1982 Feb 
Date Detail:
Created Date:  1982-04-22     Completed Date:  1982-04-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  344-8     Citation Subset:  IM    
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MeSH Terms
Amniotic Fluid / analysis*
Chromatography, Thin Layer
Diagnostic Errors
Fetal Organ Maturity
Hyaline Membrane Disease / diagnosis
Infant, Newborn
Lung / embryology*
Phosphatidylcholines / analysis*
Phosphatidylinositols / analysis
Phosphatidylserines / analysis
Prenatal Diagnosis
Sphingomyelins / analysis*
Reg. No./Substance:
0/Phosphatidylcholines; 0/Phosphatidylinositols; 0/Phosphatidylserines; 0/Sphingomyelins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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