Document Detail


Improved preservation of the rat heart with celsior solution supplemented with cariporide plus glyceryl trinitrate.
MedLine Citation:
PMID:  15996228     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our aim was to investigate whether the addition of glyceryl trinitrate (GTN), a source of nitric oxide, and/or cariporide, a Na/H exchange inhibitor, to a commercial preservation solution (Celsior) improved and extended cardiac preservation. After baseline indices of cardiac function (aortic flow, coronary flow, heart rate, cardiac output) were measured in an isolated working rat heart model, hearts were arrested and stored at 2-3 degrees C for 6 or 10 h in Celsior solution alone, Celsior supplemented with either 0.1 mg/mL GTN or 10 microM cariporide or both. After storage, functional measurements were repeated and recovery of each parameter was expressed as a percentage of its pre-storage baseline. After 6 h storage, recovery of cardiac function was significantly better in hearts stored in GTN- or cariporide-supplemented Celsior solution compared with Celsior solution alone. The beneficial effect of GTN was significantly abrogated in hearts perfused with glibenclamide prior to storage. Significant recovery of cardiac function after 10 h storage was only observed in hearts stored in Celsior solution supplemented with both GTN and cariporide. Combined supplementation with GTN and cariporide extends the safe period of storage of the rat heart and may be a useful approach to enhancing preservation of the donor heart.
Authors:
Ling Gao; Mark Hicks; Peter S MacDonald
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons     Volume:  5     ISSN:  1600-6135     ISO Abbreviation:  Am. J. Transplant.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-05     Completed Date:  2005-10-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100968638     Medline TA:  Am J Transplant     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1820-6     Citation Subset:  IM    
Affiliation:
Victor Chang Cardiac Research Institute, Heart & Lung Transplant, Sydney, New South Wales, Australia. l.gao@victorchang.unsw.edu.au
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta / physiology
Blood Flow Velocity / drug effects
Cardiac Output / drug effects
Cold Temperature
Cryopreservation / methods*
Disaccharides / therapeutic use
Drug Combinations
Electrolytes / therapeutic use
Glutamates / therapeutic use
Glutathione / therapeutic use
Guanidines / therapeutic use*
Heart*
Heart Rate / drug effects
Histidine / therapeutic use
Male
Mannitol / therapeutic use
Nitroglycerin / therapeutic use*
Organ Preservation / methods*
Organ Preservation Solutions / therapeutic use*
Rats
Rats, Wistar
Reperfusion Injury / prevention & control*
Sulfones / therapeutic use*
Chemical
Reg. No./Substance:
0/Celsior; 0/Disaccharides; 0/Drug Combinations; 0/Electrolytes; 0/Glutamates; 0/Guanidines; 0/Organ Preservation Solutions; 0/Sulfones; 0/cariporide; 55-63-0/Nitroglycerin; 69-65-8/Mannitol; 70-18-8/Glutathione; 71-00-1/Histidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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