Document Detail

Improved preservation of the rat heart with celsior solution supplemented with cariporide plus glyceryl trinitrate.
MedLine Citation:
PMID:  15996228     Owner:  NLM     Status:  MEDLINE    
Our aim was to investigate whether the addition of glyceryl trinitrate (GTN), a source of nitric oxide, and/or cariporide, a Na/H exchange inhibitor, to a commercial preservation solution (Celsior) improved and extended cardiac preservation. After baseline indices of cardiac function (aortic flow, coronary flow, heart rate, cardiac output) were measured in an isolated working rat heart model, hearts were arrested and stored at 2-3 degrees C for 6 or 10 h in Celsior solution alone, Celsior supplemented with either 0.1 mg/mL GTN or 10 microM cariporide or both. After storage, functional measurements were repeated and recovery of each parameter was expressed as a percentage of its pre-storage baseline. After 6 h storage, recovery of cardiac function was significantly better in hearts stored in GTN- or cariporide-supplemented Celsior solution compared with Celsior solution alone. The beneficial effect of GTN was significantly abrogated in hearts perfused with glibenclamide prior to storage. Significant recovery of cardiac function after 10 h storage was only observed in hearts stored in Celsior solution supplemented with both GTN and cariporide. Combined supplementation with GTN and cariporide extends the safe period of storage of the rat heart and may be a useful approach to enhancing preservation of the donor heart.
Ling Gao; Mark Hicks; Peter S MacDonald
Related Documents :
21949538 - Modified damus-kaye-stansel/dor procedure for a newborn with severe left ventricular an...
9564918 - Arrest duration influences postcardioplegia electrophysiologic recovery and reperfusion...
21877318 - Association of intrathoracic herniation of the liver with left heart hypoplasia in fetu...
6608928 - Calcium channel blockers: an intraoperative and postoperative trial in women.
17651098 - Effect of heart rate on tissue doppler measures of diastolic function.
15639478 - Transmural dispersion of repolarization as a key factor of arrhythmogenicity in a novel...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons     Volume:  5     ISSN:  1600-6135     ISO Abbreviation:  Am. J. Transplant.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-05     Completed Date:  2005-10-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100968638     Medline TA:  Am J Transplant     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1820-6     Citation Subset:  IM    
Victor Chang Cardiac Research Institute, Heart & Lung Transplant, Sydney, New South Wales, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aorta / physiology
Blood Flow Velocity / drug effects
Cardiac Output / drug effects
Cold Temperature
Cryopreservation / methods*
Disaccharides / therapeutic use
Drug Combinations
Electrolytes / therapeutic use
Glutamates / therapeutic use
Glutathione / therapeutic use
Guanidines / therapeutic use*
Heart Rate / drug effects
Histidine / therapeutic use
Mannitol / therapeutic use
Nitroglycerin / therapeutic use*
Organ Preservation / methods*
Organ Preservation Solutions / therapeutic use*
Rats, Wistar
Reperfusion Injury / prevention & control*
Sulfones / therapeutic use*
Reg. No./Substance:
0/Celsior; 0/Disaccharides; 0/Drug Combinations; 0/Electrolytes; 0/Glutamates; 0/Guanidines; 0/Organ Preservation Solutions; 0/Sulfones; 0/cariporide; 55-63-0/Nitroglycerin; 69-65-8/Mannitol; 70-18-8/Glutathione; 71-00-1/Histidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Plasmacytoid dendritic cell precursors induce allogeneic T-cell hyporesponsiveness and prolong heart...
Next Document:  Expression of CTL associated transcripts precedes the development of tubulitis in T-cell mediated ki...