Document Detail

Improved prenatal aneuploidy screening using the novel advanced first-trimester screening algorithm: a multicenter study of 10,017 pregnancies.
MedLine Citation:
PMID:  18626869     Owner:  NLM     Status:  MEDLINE    
PURPOSE:: It has been postulated that the maternal age component should be completely excluded from first-trimester screening (FTS) for fetal aneuploidies. In this study, we tested a new algorithm known as advanced first-trimester screening (AFS), which disregards maternal age. METHOD:: In a multicenter study, FTS findings were retrieved from 10,017 pregnancies. FTS risk assessment was performed using the Nicolaides method, and the AFS score was calculated. The results of both methods were compared. RESULTS:: Within this population, 81 fetuses had an abnormal karyotype. The sensitivity of the 2 algorithms was 86.4%. When the AFS method was used, the positive predictive value rose from 9.6% (FTS) to 12.4% (AFS). Using AFS, the test positive rate could be decreased by 161 cases (-22.2%) (p < 0.0001), due to a reduction of false positive cases. As a result, the false positive rate of AFS was 24.5% lower than that of FTS, while the same number of aneuploidies was detected. CONCLUSION:: AFS can markedly reduce the rate of false positive test results. If these results are confirmed by larger multicenter studies, the new AFS will represent a great improvement in fetal aneuploidy screening. (c) 2008 Wiley Periodicals, Inc. J Clin Ultrasound, 2008.
Peter Schmidt; Cindy H?rmansd?rfer; Michael Pruggmayer; Christian Sch?tte; Armin Neumann; Andreas Gerritzen; Bernhard Vaske; Peter Hillemanns; Alexander Scharf
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study    
Journal Detail:
Title:  Journal of clinical ultrasound : JCU     Volume:  36     ISSN:  1097-0096     ISO Abbreviation:  J Clin Ultrasound     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-11     Completed Date:  2009-01-06     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0401663     Medline TA:  J Clin Ultrasound     Country:  United States    
Other Details:
Languages:  eng     Pagination:  397-402     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Medical University of Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
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MeSH Terms
Chorionic Gonadotropin, beta Subunit, Human / blood
Crown-Rump Length
Fetal Diseases / epidemiology*,  genetics*,  metabolism,  ultrasonography
Genetic Testing / methods*
Maternal Age
Nuchal Translucency Measurement
Predictive Value of Tests
Pregnancy Trimester, First*
Pregnancy-Associated Plasma Protein-A / metabolism
Retrospective Studies
Risk Assessment / methods
Sensitivity and Specificity
Young Adult
Reg. No./Substance:
0/Chorionic Gonadotropin, beta Subunit, Human; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A

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