Document Detail

Improved prediction of fetal lung maturity in diabetic pregnancies: a comparison of chromatographic methods.
MedLine Citation:
PMID:  7055185     Owner:  NLM     Status:  MEDLINE    
Following planned termination of pregnancy, infants of diabetic mothers have shown a continued vulnerability to the respiratory distress syndrome (RDS), suggesting false positive results on fetal lung maturity testing. We studied the adequacy of the standard one-dimensional chromatographic lecithin/sphingomyelin (L/S) ratio for predicting RDS in 56 diabetic and 50 nondiabetic pregnancies. An exceptionally low incidence of RDS was noted for the study (0.95%) as well as for diabetic pregnancies alone (1.85%). The clinical results were further compared to a new method for determining L/S ratios and identifying other pulmonary phospholipids by two-dimensional chromatography. Values for two-dimensional L/S ratios were significantly lower from 36 through 38 weeks' gestation (P less than 0.01), suggesting improved accuracy and a lessened risk for false positive results in preterm deliveries. Positive identification of amniotic fluid phosphatidylglycerol (PG) was related to increasing L/S ratios (P = 0.001), but only 50% of nondiabetic and 16.7% of diabetic amniotic fluid samples contained PG when the L/S was 2:1 or greater (P = 0.02). The identification of PG serves to confirm fetal lung maturity, but the L/S ratio remains the best available indicator of fetal lung maturity for all high-risk pregnancies.
M D Cunningham; H E McKean; D H Gillispie; J W Greene
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  142     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1982 Jan 
Date Detail:
Created Date:  1982-03-22     Completed Date:  1982-03-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  197-204     Citation Subset:  AIM; IM    
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MeSH Terms
Chromatography / methods
False Positive Reactions
Fetal Organ Maturity
Infant, Newborn
Lung / embryology*
Phosphatidylcholines / analysis
Pregnancy in Diabetics / complications*
Respiratory Distress Syndrome, Newborn / etiology*
Sphingomyelins / analysis
Reg. No./Substance:
0/Phosphatidylcholines; 0/Sphingomyelins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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