Document Detail

Improved posthypoxic recovery with a membrane-permeable calpain inhibitor.
MedLine Citation:
PMID:  1814757     Owner:  NLM     Status:  MEDLINE    
In vitro hippocampal slices from adult rats were subjected to transient hypoxia in the presence of a cell-penetrating, calpain inhibitor (Cbz-Val-Phe-H; MDL-28170). The posthypoxic recovery of synaptic potentials was greatly improved in protease inhibitor-treated slices relative to control slices. These findings support a role for calcium-activated proteolysis in the process of hypoxic pathophysiology.
L Arlinghaus; S Mehdi; K S Lee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  209     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-06-23     Completed Date:  1992-06-23     Revised Date:  2006-05-19    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  123-5     Citation Subset:  IM    
Department of Neurological Surgery, University of Virginia, Charlottesville 22908.
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MeSH Terms
Anoxia / drug therapy*,  enzymology
Calpain / antagonists & inhibitors*
Cell Death / drug effects
Cell Membrane Permeability / drug effects
Dipeptides / pharmacology*
Hippocampus / anatomy & histology,  drug effects,  enzymology
Rats, Inbred Strains
Reg. No./Substance:
0/Dipeptides; 88191-84-8/calpain inhibitor III; EC 3.4.22.-/Calpain

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