Document Detail


Improved posthypoxic recovery with a membrane-permeable calpain inhibitor.
MedLine Citation:
PMID:  1814757     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In vitro hippocampal slices from adult rats were subjected to transient hypoxia in the presence of a cell-penetrating, calpain inhibitor (Cbz-Val-Phe-H; MDL-28170). The posthypoxic recovery of synaptic potentials was greatly improved in protease inhibitor-treated slices relative to control slices. These findings support a role for calcium-activated proteolysis in the process of hypoxic pathophysiology.
Authors:
L Arlinghaus; S Mehdi; K S Lee
Related Documents :
3918867 - Respiratory and haemodynamic effects of lateral thoracotomy or sternotomy in mechanical...
9124357 - Chronic hypoxia, glutathione-dependent detoxication, and metabolic instability in rat s...
9200217 - The action of pramiracetam on consequences of hypobaric hypoxia is only moderate.
18416247 - Hypobaric hypoxia-related impairment of pulmonary surfactant proteins a and d did not f...
7951407 - Arrest of rat embryonic development by the inhibition of gamma-glutamyl transpeptidase....
3434087 - Prevention of endotoxin-induced leukocytic infiltration of lung with radio-detoxified e...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  209     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-06-23     Completed Date:  1992-06-23     Revised Date:  2006-05-19    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  123-5     Citation Subset:  IM    
Affiliation:
Department of Neurological Surgery, University of Virginia, Charlottesville 22908.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Anoxia / drug therapy*,  enzymology
Calpain / antagonists & inhibitors*
Cell Death / drug effects
Cell Membrane Permeability / drug effects
Dipeptides / pharmacology*
Hippocampus / anatomy & histology,  drug effects,  enzymology
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Dipeptides; 88191-84-8/calpain inhibitor III; EC 3.4.22.-/Calpain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Protective effects of dazmegrel on the PAF potential of ouabain-induced cardiac arrhythmias.
Next Document:  Enhanced sensitivity to anorexia and consumption of drinking water induced by interleukin-1 beta in ...