| Improved plasma amino acids pattern following 12 months of supplemented low-protein diet in peritoneal dialysis patients. | |
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MedLine Citation:
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PMID: 20540639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Decreased plasma essential amino acid (EAA) levels, increased nonessential amino acid (NEAA) levels, and low EAA to NEAA ratio (E/NEAA) are common in peritoneal dialysis (PD) patients and may impact uremic complications. In the present study, we investigate the impact of keto acids-supplemented low-protein (sLP) diet on plasma amino acids (AAs) patterns in stable PD patients. METHODS: This is a supplemental analysis of a previously published prospective and randomized trial. Thirty-nine PD patients selected from the original population were divided to receive either low (LP: 0.6-0.8 g/kg ideal body weight [IBW]/d, n = 13), keto acids-supplemented low- (sLP: 0.6-0.8 g/kg IBW/d + 0.12 g/kg IBW/d of keto acids, n = 12), or high- (HP: 1.0-1.2 g/kg IBW/d, n = 14) protein diets and followed for 1 year. Plasma AA patterns were assessed at baseline and 12 months using high-performance liquid chromatography. RESULTS: Whereas there were no significant differences between the three groups at baseline, following 12 months, the E/NEAA had increased significantly in group sLP (0.58 +/- 0.16 to 0.83 +/- 0.20, p < 0.05), but was not different in either LP (0.62 +/- 0.20 to 0.72 +/- 0.13, p = ns) or HP (0.66 +/- 0.14 to 0.74 +/- 0.12, p = ns) group. This change in E/NEAA in group sLP was due to a significant decrease in NEAA concomitantly with maintained EAA levels, whereas in the other two groups, neither EAA nor NEAA changed significantly. CONCLUSIONS: A low-protein diet supplemented with keto acids significantly improved the pattern of plasma AA in prevalent PD patients. |
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Authors:
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Na Jiang; Jiaqi Qian; Aiwu Lin; Wei Fang; Liou Cao; Qin Wang; Zhaohui Ni; Bengt Lindholm; Jonas Axelsson; Qiang Yao |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Renal failure Volume: 32 ISSN: 1525-6049 ISO Abbreviation: Ren Fail Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-11-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8701128 Medline TA: Ren Fail Country: England |
Other Details:
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Languages: eng Pagination: 709-15 Citation Subset: IM |
Affiliation:
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Renal Division, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Center for Peritoneal Dialysis Research, Shanghai, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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blood* Diet, Protein-Restricted* Female Humans Male Middle Aged Peritoneal Dialysis* Prospective Studies Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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