Document Detail

Improved oxygenation with prostaglandin F2alpha with and without inhaled nitric oxide in dogs.
MedLine Citation:
PMID:  9516203     Owner:  NLM     Status:  MEDLINE    
Dogs of mixed breed (n = 7) were anesthetized, right lung atelectasis was established, and the cyclooxygenase pathway was blocked with ibuprofen. Measurements of pulmonary gas exchange were performed (fractional concentration of inspired O2 = 0.95) after infusions of prostaglandin F2alpha (PGF2alpha; 2 microg . kg-1 . min-1), ventilation with nitric oxide (NO; 40 ppm), or both (PGF2alpha + NO) in random order. The arterial PO2 (PaO2) under control conditions was 117 +/- 16 Torr (shunt = 33 +/- 2.5%), was unchanged with NO alone (PaO2 = 114 +/- 17 Torr; shunt = 35.7 +/- 3. 1%), but was significantly improved with PGF2alpha alone (PaO2 = 180 +/- 28 Torr; shunt = 23.2 +/- 2.8%) and with the combination of PGF2alpha + NO (PaO2 = 202 +/- 30 Torr; shunt = 20.9 +/- 2.5%). The addition of NO did not significantly enhance the effectiveness of the PGF2alpha on PaO2. Simulation of these data in a computer model, combining pulmonary gas exchange and pulmonary blood flow, reproduced the results on the basis that vasoconstriction with PGF2alpha was maximal under hypoxia in the atelectatic lung and reduced by hyperoxia in the ventilated lung, consistent with the hypothesis of O2 dependence of PGF2alpha vasoconstriction.
B E Marshall; L Chen; H F Frasch; C W Hanson; C Marshall
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  84     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-05-05     Completed Date:  1998-05-05     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1350-8     Citation Subset:  IM; S    
Center for Anesthesia Research, Department of Anesthesiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
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MeSH Terms
Administration, Inhalation
Air Pressure
Dinoprost / pharmacology*
Lung / physiopathology
Models, Biological
Nitric Oxide / administration & dosage,  pharmacology*
Oxygen / blood*
Pulmonary Atelectasis / physiopathology
Pulmonary Circulation / physiology
Pulmonary Gas Exchange / drug effects*
Respiration, Artificial
Respiratory Function Tests
Tidal Volume / physiology
Grant Support
Reg. No./Substance:
10102-43-9/Nitric Oxide; 551-11-1/Dinoprost; 7782-44-7/Oxygen

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