Document Detail


Improved oxidative stress and cardio-metabolic status in obese prepubertal children with liver steatosis treated with lifestyle combined with Vitamin E.
MedLine Citation:
PMID:  23205728     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract In obese adults with non alcoholic fatty liver disease (NAFLD), treatment with vitamin E has resulted in an improvement in liver histology, whereas variable and limited results are available in children. Our aim was to assess whether lifestyle combined with supplementation with Vitamin E might reduce oxidative stress and improve cardio-metabolic status in obese children with NAFLD. 24 obese prepubertal children (16M) followed a 6-month lifestyle intervention combined with vitamin E supplementation (600 mg/day) and compared with 21 age and sex-matched obese peers who underwent lifestyle intervention only. At baseline and after 6-month urinary prostaglandin F2α (PGF-2α); endogenous secretory receptor for advanced glycation end products (esRAGE), high sensitivity C-reactive protein (hs-CRP), alanine aminotransferases (ALT), lipid profile, glucose and insulin were assessed. The two groups were comparable for age (8.3±1.6 vs 8.4±1.3 yr), sex and BMI SDS (2.16±0.29 vs 2.13±0.28). At the beginning of the study, PGF2-α, esRAGE and hsCRP, ALT, lipid profile and HOMA-IR levels were similar between the two groups (all p>0.05). After 6-month treatment, levels of PGF2-α (p<0.001) significantly decreased and esRAGE significantly increased (p<0.001) in children treated with vitamin E. A significant reduction was also found in ALT (p=0.001), lipid profile and HOMA-IR (p<0.001). In contrast, no significant change in any of these markers was detected in the lifestyle only group. In conclusion, vitamin E supplementation was associated with a significant reduction in oxidative stress and improved cardio-metabolic alterations. These data suggest that Vitamin E supplementation could represent a valuable treatment in obese children affected by NAFLD.
Authors:
Ebe D'Adamo; M Loredana Marcovecchio; Cosimo Giannini; Tommaso de Giorgis; Valentina Chiavaroli; Francesco Chiarelli; Angelika Mohn
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-4
Journal Detail:
Title:  Free radical research     Volume:  -     ISSN:  1029-2470     ISO Abbreviation:  Free Radic. Res.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423872     Medline TA:  Free Radic Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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