Document Detail

Improved neuromagnetic detection of fetal and neonatal auditory evoked responses.
MedLine Citation:
PMID:  11336893     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the quality of fetal and neonatal auditory evoked responses (fAERs and nAERs) obtainable with a low-noise, high-channel count SQUID gradiometer in a well-shielded environment. METHODS: Measurement of long-latency fAERs was attempted in 19 normal fetuses in 28 sessions at 29-40 weeks' gestation, using a 37-channel SQUID gradiometer. Postnatal measurement was attempted in 16 neonates in 25 sessions at age 2-6 weeks. RESULTS: Signals of amplitude 8 fT or greater were detected in 15 of 28 fetal measurement sessions, yielding a higher success rate (54%) than in a previous study of ours. Signals of amplitude greater than 25 fT were detected in 23 of 25 (92%) of neonatal measurement sessions. The spatial and temporal characteristics of the signals were studied in greater detail. Dipole patterns consistent with a source in the auditory cortex were observable in nearly all neonates and in many fetuses. The dominant component of the nAER was compatible with the P250 seen in neonatal EEG recordings; however, the largest component of the fAERs had longer latency and in many subjects had opposite polarity. CONCLUSION: A higher success rate, earlier detection, and improved characterization of signal morphology and topography were demonstrated for fAER recordings.
J M Lengle; M Chen; R T Wakai
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  112     ISSN:  1388-2457     ISO Abbreviation:  Clin Neurophysiol     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-04     Completed Date:  2001-06-28     Revised Date:  2008-09-10    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  785-92     Citation Subset:  IM    
Department of Medical Physics, University of Wisconsin-Madison, 1300 University Avenue, Madison, WI, USA.
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MeSH Terms
Acoustic Stimulation
Brain / embryology,  physiology*
Evoked Potentials, Auditory / physiology*
Fetus / physiology*
Gestational Age
Infant, Newborn / physiology*
Reaction Time
Grant Support

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