| Improved myocardial preservation during cold storage using substrate enhancement. | |
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MedLine Citation:
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PMID: 1973349 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was undertaken to determine whether substrate enhancement with L-glutamate during periods of cold storage would improve ventricular function in transplanted hearts. Thirty-one rabbit hearts were rapidly excised and perfused with Krebs-Henseleit buffer (37 degrees C) on a Langendorff apparatus. They were arrested with hypothermic (4 degrees C), crystalloid, potassium (25 mEq/L) cardioplegia and stored at 3 degrees C for three hours, followed by reperfusion with Krebs-Henseleit buffer for one hour. Hearts were treated in one of several ways: Group 1 (n = 8) did not receive any L-glutamate and serve as controls; group 2 (n = 8) had L-glutamate (4 mmol/L) added to both the cardioplegic and reperfusate solutions; group 3 (n = 5) received L-glutamate only before ischemia; group 4 (n = 5) received L-glutamate only in the cardioplegic solution; and group 5 (n = 5) received L-glutamate only in the reperfusate. Hearts receiving L-glutamate in the reperfusate with or without its addition to the cardioplegic solution (groups 2 and 5) had the best recovery of the first derivative of positive and negative change in left ventricular peak systolic pressure and no significant changes in left ventricular compliance. Pretreatment with L-glutamate alone (group 3) resulted in no better recovery than in group 1 hearts. We conclude that addition of L-glutamate to reperfusate solutions after periods of cold storage for transplantation enhances the recovery of ventricular function. |
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Authors:
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C K Haan; H L Lazar; S Rivers; C Coady; R J Shemin |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 50 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 1990 Jul |
Date Detail:
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Created Date: 1990-08-13 Completed Date: 1990-08-13 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 80-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiothoracic Surgery, Boston University Medical Center, Massachusetts. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / physiology Cardiac Output / physiology Cardioplegic Solutions / administration & dosage Coronary Circulation / physiology Cryopreservation / methods* Glutamates / administration & dosage, therapeutic use* Glutamic Acid Heart / physiology* Heart Transplantation / methods*, physiology Hypothermia, Induced Myocardial Contraction / physiology Myocardial Reperfusion / methods Rabbits Time Factors Tissue Preservation / methods* |
| Grant Support | |
ID/Acronym/Agency:
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507-RR-05487/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cardioplegic Solutions; 0/Glutamates; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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