| Improved method of canine decerebration. | |
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MedLine Citation:
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PMID: 9688755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe an improved decerebration method for dogs that is suitable for studies of brain stem neurons in the absence of anesthesia. Previously reported techniques of canine decerebration often lead to respiratory and hemodynamic instability and lack of typical decerebrate rigidity. We have developed a precise, visually controlled, midcollicular brain stem transection technique that overcomes these problems. Our method results in only moderate blood loss while preserving carotid and basilar artery circulations. Consistent levels of brain stem transection routinely lead to stable postdecerebration hemodynamic parameters, allowing prolonged brain stem neuronal recordings. The same model should also be useful for a variety of studies involving other physiological systems in dogs in the absence of anesthesia and for studies of anesthetic effects. |
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Authors:
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M Tonkovic-Capin; M Krolo; E A Stuth; F A Hopp; E J Zuperku |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 85 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-09-03 Completed Date: 1998-09-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 747-50 Citation Subset: IM |
Affiliation:
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Zablocki Department of Veterans Affairs Medical Center, and Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53295, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia Animals Blood Loss, Surgical Blood Pressure / physiology Brain / anatomy & histology, surgery Brain Stem / physiology, surgery Carbon Dioxide / blood Decerebrate State / physiopathology* Dogs Heart Rate / physiology Respiratory Mechanics |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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