Document Detail

Improved metabolic control and hepatic oxidative biomarkers with the periconception use of Helichrysum plicatum ssp. plicatum.
MedLine Citation:
PMID:  20143969     Owner:  NLM     Status:  MEDLINE    
Our aim was to investigate the hypoglycaemic and antioxidant effects of the Helichrysum plicatum ssp. plicatum (HPsP) plant extract in the streptozotocin-induced type 1 diabetes rat model during pregnancy. Five groups (n = 8, each) were formed: (1) diabetic non-mated control, (2) non-diabetic mated control, (3) diabetic mated control, (4) diabetic non-mated treatment and (5) diabetic mated treatment. The HPsP extract was administered orally for 15 days (250 mg/kg body weight), beginning 3 days before mating. The extract led to decreased blood glucose, increased serum insulin, and decreased serum triglycerides in pregnant and non-pregnant diabetic animals. Liver thiobarbituric acid reactive substances (TBARS) and reduced glutathione (GSH) measurements in extract-treated diabetics were similar to non-diabetic pregnant controls, indicating probable reversal of increased lipid peroxidation in the liver. The mean pup number tended to increase (p = 0.06) with extract administration. In conclusion, the beneficial effects we encountered with the periconception use of the studied herbal extract warrant further investigation.
M Sezik; M Aslan; D D Orhan; E Erdemoglu; M Pekcan; T Mungan; E Sezik
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology     Volume:  30     ISSN:  1364-6893     ISO Abbreviation:  J Obstet Gynaecol     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-10     Completed Date:  2010-05-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309140     Medline TA:  J Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  127-31     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
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MeSH Terms
Blood Glucose / analysis
Diabetes Mellitus, Experimental / drug therapy*
Drug Evaluation, Preclinical
Glutathione / analysis
Insulin / blood
Lipid Peroxidation
Liver / metabolism
Oxidative Stress
Plant Extracts / therapeutic use*
Plants, Medicinal
Pregnancy in Diabetics / drug therapy*
Rats, Wistar
Thiobarbituric Acid Reactive Substances / analysis
Triglycerides / blood
Reg. No./Substance:
0/Blood Glucose; 0/Plant Extracts; 0/Thiobarbituric Acid Reactive Substances; 0/Triglycerides; 11061-68-0/Insulin; 70-18-8/Glutathione

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