| Improved left ventricular function after short-term treatment with fructose-1,6-diphosphate: echocardiographic study in chronic ischemic heart disease and idiopathic dilated cardiomyopathy. | |
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MedLine Citation:
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PMID: 2978875 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of fructose-1,6-diphosphate (FDP) on left ventricular function was assessed in seven patients with chronic ischemic heart disease and eight patients with idiopathic dilated cardiomyopathy. In a crossover study design each patient received 10 gm of FDP or saline placebo intravenously for three days. An M-mode echocardiographic assessment of left ventricular (LV) function was made before and after each treatment period. After FDP treatment, LV end-diastolic and systolic dimensions showed a 6% reduction (P less than 0.01), while peak lengthening rate of LV dimension in diastole and peak shortening rate of LV dimension in systole increased 17% and 10%, respectively (P less than 0.05). There was evidence that FDP was more effective in the patients with ischemic heart disease than in the patients with cardiomyopathy. |
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Authors:
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A M Grandi; C Muggia; F Barzizza; A Venco; G Finardi |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Clinical therapeutics Volume: 10 ISSN: 0149-2918 ISO Abbreviation: Clin Ther Publication Date: 1988 |
Date Detail:
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Created Date: 1990-07-26 Completed Date: 1990-07-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7706726 Medline TA: Clin Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 372-80 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine and Medical Therapeutics, University of Pavia-IRCCS, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cardiomegaly / drug therapy Cardiomyopathy, Dilated / drug therapy, physiopathology Chronic Disease Clinical Trials as Topic Coronary Disease / drug therapy, physiopathology Echocardiography Female Fructosediphosphates / pharmacology, therapeutic use* Heart / drug effects*, physiopathology Heart Ventricles / drug effects, physiopathology Hexosediphosphates / therapeutic use* Humans Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Fructosediphosphates; 0/Hexosediphosphates; 488-69-7/fructose-1,6-diphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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