Document Detail

Improved left ventricular function after short-term treatment with fructose-1,6-diphosphate: echocardiographic study in chronic ischemic heart disease and idiopathic dilated cardiomyopathy.
MedLine Citation:
PMID:  2978875     Owner:  NLM     Status:  MEDLINE    
The effect of fructose-1,6-diphosphate (FDP) on left ventricular function was assessed in seven patients with chronic ischemic heart disease and eight patients with idiopathic dilated cardiomyopathy. In a crossover study design each patient received 10 gm of FDP or saline placebo intravenously for three days. An M-mode echocardiographic assessment of left ventricular (LV) function was made before and after each treatment period. After FDP treatment, LV end-diastolic and systolic dimensions showed a 6% reduction (P less than 0.01), while peak lengthening rate of LV dimension in diastole and peak shortening rate of LV dimension in systole increased 17% and 10%, respectively (P less than 0.05). There was evidence that FDP was more effective in the patients with ischemic heart disease than in the patients with cardiomyopathy.
A M Grandi; C Muggia; F Barzizza; A Venco; G Finardi
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical therapeutics     Volume:  10     ISSN:  0149-2918     ISO Abbreviation:  Clin Ther     Publication Date:  1988  
Date Detail:
Created Date:  1990-07-26     Completed Date:  1990-07-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7706726     Medline TA:  Clin Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  372-80     Citation Subset:  IM    
Department of Internal Medicine and Medical Therapeutics, University of Pavia-IRCCS, Italy.
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MeSH Terms
Cardiomegaly / drug therapy
Cardiomyopathy, Dilated / drug therapy,  physiopathology
Chronic Disease
Clinical Trials as Topic
Coronary Disease / drug therapy,  physiopathology
Fructosediphosphates / pharmacology,  therapeutic use*
Heart / drug effects*,  physiopathology
Heart Ventricles / drug effects,  physiopathology
Hexosediphosphates / therapeutic use*
Middle Aged
Reg. No./Substance:
0/Fructosediphosphates; 0/Hexosediphosphates; 488-69-7/fructose-1,6-diphosphate

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