| Improved in vitro fertilization embryo quality and pregnancy rates with intracytoplasmic sperm injection of sperm from fresh testicular biopsy samples vs. frozen biopsy samples. | |
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MedLine Citation:
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PMID: 15589855 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the outcomes of first-attempt IVF-intracytoplasmic sperm injection (ICSI) cycles when using fresh testicular biopsy samples vs. frozen biopsy samples. DESIGN: Retrospective chart review of 92 consecutive first-attempt IVF-ICSI cycles. SETTING: Two IVF programs. PATIENT(S): Forty consecutive first-attempt IVF-ICSI patients using sperm from fresh testicular biopsy samples and 52 consecutive first-attempt IVF-ICSI cycles using frozen testicular biopsy samples. INTERVENTION(S): Testicular biopsy, IVF-ICSI with fresh and frozen-thawed spermatozoa. MAIN OUTCOME MEASURE(S): Fertilization rates, embryo quality, pregnancy, delivery, and spontaneous abortion rates. RESULT(S): A significantly increased ICSI fertilization percentage was obtained with frozen testicular biopsy samples (76.5% +/- 3.1%) vs. fresh biopsy samples (68.3% +/- 2.6%). However, embryo quality, pregnancy, and delivery rates were higher in the fresh biopsy group. Mean embryo score was 4.54 +/- 0.31 and 3.62 +/- 0.2 in the fresh vs. frozen group, respectively. Chemical pregnancy rates (60% vs. 49.1%), clinical pregnancy rates (56.4% vs. 41.2%), and delivery rates (48.7% vs. 31.2%) were each higher in the fresh group vs. frozen group. Accordingly, the spontaneous abortion rate was lower in the fresh group (21.7%) vs. the frozen group (33.3%). CONCLUSION(S): Although the use of frozen biopsy samples has logistical advantages, we conclude it may be advantageous to use fresh testicular biopsy samples in IVF-ICSI cases whenever possible, as fresh specimens yielded significantly improved embryo quality, generally higher pregnancy rates, and lower spontaneous abortion rates. |
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Authors:
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Vincent W Aoki; Aaron L Wilcox; Cindy Thorp; Blake D Hamilton; Douglas T Carrell |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Fertility and sterility Volume: 82 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-12-13 Completed Date: 2005-01-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 1532-5 Citation Subset: IM |
Affiliation:
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Department of Surgery (Urology), University of Utah School of Medicine, Salt Lake City, Utah 84108, USA. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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epidemiology Biopsy Delivery, Obstetric Embryo, Mammalian / physiology* Female Fertilization in Vitro* Freezing* Humans Incidence Male Pregnancy Pregnancy Rate* Retrospective Studies Sperm Injections, Intracytoplasmic* Testis / pathology* Tissue and Organ Harvesting / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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