| Improved imaging of liver metastases with stimulated acoustic emission in the late phase of enhancement with the US contrast agent SH U 508A: early experience. | |
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MedLine Citation:
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PMID: 10207423 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To see whether stimulated acoustic emission (SAE) in the liver parenchyma in the late phase of enhancement with SH U 508A increases the conspicuity of occult metastases at ultrasonography (US). MATERIALS AND METHODS: Eighteen patients with known hypo- or hypervascular hepatic metastases underwent US after SH U 508A administration, after a delay of at least 5 minutes, to ensure decay of blood pool enhancement. In 16 patients with visible metastases, conspicuity was compared on registered SAE and gray-scale scans by two blinded readers and by using computerized analysis of relative gray-scale and color Doppler conspicuity scores inside and outside the lesion. In nine patients, areas suspected of being involved but without definite gray-scale masses were imaged in the same way. Paired sections were analyzed by two blinded readers looking for parenchymal color defects without corresponding gray-scale masses; nine control images from three healthy volunteers were also included. RESULTS: Intense, transient parenchymal SAE was seen in all subjects. All metastases appeared as areas of reduced or absent signal. The conspicuity score was 80% for SAE versus 9% for gray-scale US (P < .001, Wilcoxon signed rank test). SAE-specific defects were seen in all patients but in none of the volunteers. Metastases seen on SAE but undetectable on gray-scale images were proved in three patients. CONCLUSION: SAE with SH U 508A improves the conspicuity of metastases. SAE-specific defects may reveal isoechoic or subtle metastases. |
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Authors:
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M J Blomley; T Albrecht; D O Cosgrove; N Patel; V Jayaram; J Butler-Barnes; R J Eckersley; A Bauer; R Schlief |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Radiology Volume: 210 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 1999 Feb |
Date Detail:
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Created Date: 1999-05-05 Completed Date: 1999-05-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 409-16 Citation Subset: AIM; IM |
Affiliation:
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Department of Imaging, Hammersmith Hospital, London, England. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biopsy Contrast Media* Female Humans Image Processing, Computer-Assisted Liver / pathology, ultrasonography Liver Neoplasms / secondary*, ultrasonography* Male Middle Aged Pilot Projects Polysaccharides / diagnostic use* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Polysaccharides; 127279-08-7/SHU 508 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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