Document Detail


Improved estimation of postmortem interval based on differential behaviour of vitreous potassium and hypoxantine in death by hanging.
MedLine Citation:
PMID:  11852204     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many formulae are available to estimate the relation between the potassium ([K+]) and hypoxantine ([Hx]) concentration in the vitreous humour and the postmortem interval (PMI). Typically these have been based on a correlation test and linear regression using the postmortal interval as the independent variable and [K+] or [Hx] as the dependent variable in order to estimate the confidence interval. However, a recent study has shown that a more precise measurement of PMI can be obtained if [K+] is used as the independent variable. The regression lines obtained from the most recent deceased subjects with forensic relevance received for autopsy in the Institute of Legal Medicine are [K+] = 5.589 + 0.174PMI and [Hx] = 26.459 + 3.017PMI, by changing the variables, we obtain PMI=3.967[K+] - 19.186 (R2 = 0.688, P < 0.001) and PMI = 0.172 [Hx] + 0.170 (R2 = 0.518, P < 0.001). In this paper we propose the cause of death as an extra factor which modifies the relationship and gives even greater precision in estimating PMI. In cases of death by hanging the results are considerably improved with [K+] = 5.224 + 0.225PMI and [Hx] = 15.161+4.957PMI, respectively, and consequently, PMI = 3.631[K+] - 17.334 (R2 = 0.818, P< 0.001) and PMI = 0.153[Hx] - 0.368 (R2 = 0.757, P < 0.001): the slope is less and the precision is obviously enhanced.
Authors:
José I Muñoz Barús; JoséM Suárez-Peñaranda; Xosé L Otero; María S Rodríguez-Calvo; Eduardo Costas; Xoán Miguéns; Luis Concheiro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Forensic science international     Volume:  125     ISSN:  0379-0738     ISO Abbreviation:  Forensic Sci. Int.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-03-07     Completed Date:  2002-04-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902034     Medline TA:  Forensic Sci Int     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  67-74     Citation Subset:  IM    
Affiliation:
Institute of Legal Medicine, School of Medicine, C/San Francisco s/n, University of Santiago de Compostela, 15782 Galicia, Spain. barusiml@usc.es
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MeSH Terms
Descriptor/Qualifier:
Asphyxia / metabolism*
Autopsy
Creatinine / analysis
Female
Forensic Medicine / methods
Humans
Hypoxanthine / analysis*
Male
Postmortem Changes
Potassium / analysis*
Sensitivity and Specificity
Time Factors
Urea / analysis
Vitreous Body / chemistry*
Chemical
Reg. No./Substance:
57-13-6/Urea; 60-27-5/Creatinine; 68-94-0/Hypoxanthine; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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