Document Detail


Improved dissolution behavior of lipophilic drugs by solid dispersions: the production process as starting point for formulation considerations.
MedLine Citation:
PMID:  21722000     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Many new drug substances have low aqueous solubility which can cause poor bioavailability after oral administration. The application of solid dispersions is a useful method to increase the dissolution rate of these drugs and thereby improve their bioavailability. So far, several methods have been developed to prepare solid dispersions. To obtain a product with the desired attributes, both the formulation and production processes should be considered.
AREAS COVERED: The most currently used methods to produce solid dispersions, such as the fusion method, hot melt extrusion, spray drying, freeze drying and supercritical fluid precipitation, are reviewed in this paper. In addition, the physicochemical characteristics of the obtained solid dispersions are discussed.
EXPERT OPINION: Solid dispersions can be successfully prepared by simple fusion, hot melt extrusion, spray drying, freeze drying and supercritical fluid precipitation. Hot melt extrusion, spray drying and freeze drying are processes that can be applied for large scale production. The simple fusion method is not very suitable for large scale production, but is particularly suitable for screening formulations. The most recent method to produce sold dispersions is supercritical fluid precipitation. The process conditions of this method need extensive investigation, in particular in relationship with the selection of the type of carrier and/or solvent. Both processes and formulation aspects strongly affect the characteristics of solid dispersion products. Furthermore, application of crystalline solid dispersions is gaining increasing interest because they are thermodynamically more stable than amorphous solid dispersions.
Authors:
Parinda Srinarong; Hans de Waard; Henderik W Frijlink; Wouter L J Hinrichs
Publication Detail:
Type:  Journal Article; Review     Date:  2011-07-02
Journal Detail:
Title:  Expert opinion on drug delivery     Volume:  8     ISSN:  1744-7593     ISO Abbreviation:  Expert Opin Drug Deliv     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-22     Completed Date:  2011-12-22     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101228421     Medline TA:  Expert Opin Drug Deliv     Country:  England    
Other Details:
Languages:  eng     Pagination:  1121-40     Citation Subset:  IM    
Affiliation:
University of Groningen, Department of Pharmaceutical Technology and Biopharmacy, Groningen, The Netherlands. P.srinarong@rug.nl
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Biological Availability
Chemistry, Pharmaceutical
Decision Trees
Drug Carriers / administration & dosage,  chemistry,  pharmacokinetics
Drug Compounding / methods*
Humans
Hydrophobic and Hydrophilic Interactions
Pharmaceutical Preparations / administration & dosage*,  chemistry*
Pharmaceutical Vehicles / chemistry
Pharmacokinetics*
Physicochemical Phenomena
Solubility
Suspensions
Chemical
Reg. No./Substance:
0/Drug Carriers; 0/Pharmaceutical Preparations; 0/Pharmaceutical Vehicles; 0/Suspensions

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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