Document Detail

Improved diastolic function after myoblast transplantation in a model of ischemia-infarction.
MedLine Citation:
PMID:  19016109     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The aim of this study was to evaluate the effect of myoblast transplantation on left ventricular function, perfusion, and scar formation after compromised coronary flow. DESIGN: A coronary vessel with Ameroid-induced stenosis was ligated and skeletal muscle was biopsied for isolation and cultivation of myoblasts. Two weeks after ligation, animals were randomly selected to receive intramyocardial injections of 2 x 10(6) myoblasts or vehicle. Fifteen animals survived the whole study period (n=9 and n=6, respectively). All animals underwent cardiac magnetic resonance imaging (MRI) and angiography pretreatment and four weeks posttreatment. RESULTS: Peak filling rate of the left ventricle improved in the myoblast group (p=0.0048), but not in the control group. Peak ejection rate and duration of diastole improved only in the myoblast group (p=0.049 and p=0.0039, respectively). Ejection fraction or local thickening did not change. Fibrosis and perfusion were similar in both groups, but more microvessels were present histologically in the myoblast group. CONCLUSIONS: In this preclinical study, autologous myoblast transplantation improved ischemic heart function via enhanced diastolic filling of the left ventricle.
Tommi Pätilä; Tuija Ikonen; Esko Kankuri; Aki Uutela; Jyri Lommi; Leena Krogerus; Pertteli Salmenperä; Josef Bizik; Kirsi Lauerma; Ari Harjula
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian cardiovascular journal : SCJ     Volume:  43     ISSN:  1651-2006     ISO Abbreviation:  Scand. Cardiovasc. J.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-20     Completed Date:  2009-05-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708377     Medline TA:  Scand Cardiovasc J     Country:  England    
Other Details:
Languages:  eng     Pagination:  100-9     Citation Subset:  IM    
Department of Cardiothoracic Surgery, University of Helsinki Meilahti Hospital, Finland.
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MeSH Terms
Cells, Cultured
Coronary Angiography
Coronary Circulation
Disease Models, Animal
Magnetic Resonance Imaging
Myoblasts, Skeletal / transplantation*
Myocardial Contraction*
Myocardial Infarction / etiology,  pathology,  physiopathology,  surgery*
Myocardial Ischemia / complications,  pathology,  physiopathology,  surgery*
Myocardium / pathology
Stroke Volume
Time Factors
Transplantation, Autologous
Ventricular Function, Left*

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