Document Detail


Improved diastolic LV filling after acute application of ajmaline in patients with coronary artery disease and normal systolic LV function.
MedLine Citation:
PMID:  2364583     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine whether ajmaline (A) can be safely applied in coronary artery disease (CAD), changes of left ventricular (LV) function after acute ajmaline application were analyzed by pulsed Doppler echocardiography in 10 CAD patients. LV pressures in systole and end-diastole and LVEF remained normal and comparable. Doppler normalized peak filling rate (p less than 0.02), peak early/atrial filling velocity (E/A) ratio (p less than 0.01) and E-deceleration (p less than 0.05) increased. The increase in E/A and in E-deceleration relative to base values was directly correlated (p less than 0.001). PEP increased, LVET remained unchanged. LV diastolic filling is improved after acute application of ajmaline in patients with CAD and normal systolic function; its application may be advised not only for therapy of arrhythmia but also to improve left ventricular diastolic mechanics in these patients.
Authors:
J Hüting; J Thormann; V Mitrovic; M Schlepper
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  13     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-08-13     Completed Date:  1990-08-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  485-9     Citation Subset:  IM    
Affiliation:
Kerckhoff-Klinik, Max-Planck-Society, Bad Nauheim, Federal Republic of Germany.
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MeSH Terms
Descriptor/Qualifier:
Aged
Ajmaline / administration & dosage,  therapeutic use*
Coronary Disease / drug therapy*,  physiopathology
Diastole / drug effects
Echocardiography
Echocardiography, Doppler
Female
Heart / drug effects*,  physiopathology
Heart Ventricles / drug effects,  physiopathology
Humans
Infusions, Intravenous
Male
Middle Aged
Regression Analysis
Systole
Chemical
Reg. No./Substance:
4360-12-7/Ajmaline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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