Document Detail


Improved diagnosis and management of hyper- and hypothyroidism by timing the arterial sounds.
MedLine Citation:
PMID:  1262433     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
"Sphygmo-Recording," a non-invasive method for timing the arterial pulse wave contour provides an objective measure of responses to medication in patients with hyper- and hypothyroidism. The QKd interval, i.e., the interval from the onset of the QRS complex (Q) to the onset of the Korotkoff sounds (K) at the brachial artery when the sphygmomanometer cuff is at diastolic pressure (d) is the QKd interval. QKd is normally 205 +/- 12 msec. In the hyperthyroidism the QKd interval may be shortened to 110 msec. In hypothyroidism the QKd interval may be prolonged to 320 msec. Changes in QKd parallel changes in clinical status and serum total T4 and T3, measured by radioimmunoassay. QKd can be used as an objective guide to antithyroid therapy in hyperthyroidism and replacement therapy with thyroid hormone in hypothyroid individuals.
Authors:
R T Young; A J Van Herle; D Rodbard
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  42     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1976 Feb 
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  330-40     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Pressure Determination / instrumentation
Electrocardiography / instrumentation
Female
Hemodynamics
Humans
Hyperthyroidism / diagnosis*,  physiopathology
Hypothyroidism / diagnosis*,  physiopathology
Male
Middle Aged
Thyrotropin / blood
Thyroxine / blood
Time Factors
Triiodothyronine / blood
Chemical
Reg. No./Substance:
6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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