Document Detail

Improved detection of minor ischemic myocardial injury with measurement of serum cardiac troponin I.
MedLine Citation:
PMID:  9365387     Owner:  NLM     Status:  MEDLINE    
This study compared the diagnostic accuracy of the measurement of serum cardiac troponin I (cTnI) with creatine kinase (CK) MB mass in patients with minor myocardial injury whose measured total CK activity did not exceed twice the upper reference limit (300 U/L for men; 200 U/L for women). Forty-eight consecutive patients presenting with chest pain and with in-hospital documentation of myocardial injury were enrolled. Electrocardiogram, echocardiogram, and serial serum CK-MB mass, cTnI, and total CK were measured over 36 h after admission. Peak total CK activity was within normal limits in 28 patients (58%). The mean (+/- SD) peak CK-MB mass and cTnI concentrations were: 16.4 (11.8) micrograms/L and 132 (13.0) micrograms/L; respectively. The peak biochemical marker index (defined as CK-MB or cTnI divided by its respective upper reference limit) was significantly (P < 0.05) higher for cTnI than for CK-MB from 7 to 36 h. The clinical sensitivity for detection of myocardial injury for cTnI was 100% [95% confidence interval (CI): 87.2% to 100%], compared with 81.8% (CI: 67.3% to 91.8%) for CK-MB. Thus, cTnI was more sensitive than CK-MB mass for detection of myocardial injury in patients with small increases of total CK.
F S Apple; A Falahati; P R Paulsen; E A Miller; S W Sharkey
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical chemistry     Volume:  43     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1997-12-08     Completed Date:  1997-12-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2047-51     Citation Subset:  IM    
Clinical Laboratories 812, Hennepin County Medical Center, Minneapolis, MN, USA.
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MeSH Terms
Acute Disease
Aged, 80 and over
Biological Markers / blood
Creatine Kinase / blood
Middle Aged
Myocardial Ischemia / blood*,  diagnosis,  ultrasonography
Retrospective Studies
Sensitivity and Specificity
Troponin I / blood*
Reg. No./Substance:
0/Biological Markers; 0/Isoenzymes; 0/Troponin I; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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