Document Detail

Improved detection and localization of lower gastrointestinal hemorrhage using subtraction scintigraphy: clinical evaluation.
MedLine Citation:
PMID:  17496006     Owner:  NLM     Status:  MEDLINE    
Does subtraction scintigraphy improve the diagnostic utility of scintigraphic evaluation in acute lower gastrointestinal hemorrhage? METHODS: This research was a retrospective clinical study using a repeat-measures design of randomized control and experimental groups. A single patient dataset provided both the control group (conventional scintigraphy) and the experimental group (conventional and subtraction techniques). Forty-nine raw (99m)Tc-red blood cell studies were randomized and interpreted by 4 independent physicians as conventional scintigraphy data only (round 1). The conventional scintigraphy studies were combined with subtraction images and randomized for reinterpretation (round 2). RESULTS: Although there was a decrease in the mean, no statistically significant difference was noted between the mean time to bleed detection between interpretive rounds 1 and 2 (P = 0.524). The addition of subtraction scintigraphy to the interpretation process changed the outcome from "probably present" to "absent" for 14% of patients and from "equivocal" to "absent" for another 12%, and this change had a marked effect on the false-positive rate. The false-positive rate decreased from 9.6% in round 1 to 3.6% in round 2. Receiver operator characteristic analysis showed that combining conventional scintigraphy with subtraction scintigraphy improved test performance. CONCLUSION: False-positive studies can be reduced by using subtraction scintigraphy in conjunction with conventional scintigraphy in the interpretive process.
Geoffrey M Currie; Philip A Towers; Janelle M Wheat
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Publication Detail:
Type:  Journal Article     Date:  2007-05-11
Journal Detail:
Title:  Journal of nuclear medicine technology     Volume:  35     ISSN:  0091-4916     ISO Abbreviation:  J Nucl Med Technol     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-31     Completed Date:  2007-08-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0430303     Medline TA:  J Nucl Med Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  105-11     Citation Subset:  IM    
School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, Australia.
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MeSH Terms
Aged, 80 and over
Gastrointestinal Hemorrhage / radionuclide imaging*
Image Enhancement / methods*
Image Interpretation, Computer-Assisted / methods*
Middle Aged
Reproducibility of Results
Retrospective Studies
Sensitivity and Specificity
Subtraction Technique*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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