Document Detail

Improved detection of ischemia-induced increases in coronary sinus adenosine in patients with coronary artery disease.
MedLine Citation:
PMID:  1541009     Owner:  NLM     Status:  MEDLINE    
Attempts to monitor coronary sinus adenosine as a clinical marker of myocardial ischemia in humans have been disappointing. Accordingly, procedures have been developed for detecting adenosine in blood collected from the human coronary sinus. Collection involves using a double-lumen metabolic catheter, which allows blood to be mixed with a stop solution at the catheter tip, thereby minimizing adenosine formation and degradation. A five-component stop solution almost completely arrests adenosine formation and degradation. Adenosine analysis is improved by using both boronate and C18 Sep-Pak columns to purify and concentrate adenosine in human plasma before HPLC. Plasma adenosine in the coronary sinus of patients with and without coronary artery disease, measured before and during peak atrial pacing, showed a twofold atrial pacing-induced increase in adenosine in the patients with coronary artery disease (n = 9, P less than 0.001) but no change in the patients with normal epicardial coronary arteries (n = 6). These preliminary results indicate that coronary sinus adenosine may provide an index of myocardial ischemia in patients with coronary artery disease.
M D Feldman; C R Ayers; M R Lehman; H E Taylor; V L Gordon; P J Sabia; D Ras; T C Skalak; J Linden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical chemistry     Volume:  38     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-04-03     Completed Date:  1992-04-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  256-62     Citation Subset:  IM    
Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908.
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MeSH Terms
Adenosine / blood*
Adenosine Deaminase / metabolism
Blood Specimen Collection
Cardiac Pacing, Artificial
Chromatography, High Pressure Liquid
Coronary Disease / blood*,  physiopathology
Heart Catheterization
Heart Rate
Quality Control
Sinus of Valsalva*
Reg. No./Substance:
58-61-7/Adenosine; EC Deaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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