Document Detail

Improved control of brittle Parkinsonism by separate administration of levodopa and benserazide.
MedLine Citation:
PMID:  6802383     Owner:  NLM     Status:  MEDLINE    
A 59-year-old woman who had had Parkinsonism for 12 years was treated with orphenadrine and levodopa combined with a dopa carboxylase inhibitor. The initial response was good, but after several years' treatment her condition alternated between severe bradykinesia and incapacitating, violent chorea, interspersed with short periods of mobility. A new regimen was devised, using levodopa in capsules of 40 mg and benserazide in separate capsules of 10 or 25 mg. Levodopa 40 mg was taken at intervals of half to two and a half hours, usually with benserazide 10 mg but alone in the late morning and evening. Additional benserazide was required one hour after lunch. With this regimen her condition was greatly improved, though she still had an abnormal gait and spells of bradykinesia and chorea. Separate, frequent small doses of levodopa and benserazide may give better control of brittle Parkinsonism.
D L McLellan; B C Dean
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  British medical journal (Clinical research ed.)     Volume:  284     ISSN:  0267-0623     ISO Abbreviation:  Br Med J (Clin Res Ed)     Publication Date:  1982 Apr 
Date Detail:
Created Date:  1982-06-21     Completed Date:  1982-06-21     Revised Date:  2008-11-20    
Medline Journal Info:
Nlm Unique ID:  8302911     Medline TA:  Br Med J (Clin Res Ed)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1001-2     Citation Subset:  IM    
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MeSH Terms
Benserazide / administration & dosage*
Drug Administration Schedule
Hydrazines / administration & dosage*
Levodopa / administration & dosage*
Middle Aged
Parkinson Disease / drug therapy*
Time Factors
Reg. No./Substance:
0/Hydrazines; 0/Levodopa; 322-35-0/Benserazide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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