Document Detail

Improved bone mineral status in very low birthweight infants fed human milk mixed with preterm formula.
MedLine Citation:
PMID:  2504028     Owner:  NLM     Status:  MEDLINE    
The bone mineral status of very low birthweight (VLBW) infants fed exclusively their own mother's milk (group I) was compared with that of VLBW infants fed mother's milk in the initial 4 weeks followed by a 1:1 mixture of mother's milk and preterm formula containing high phosphorus (P) and calcium (Ca) (group II). In both groups, most infants showed a biochemical picture characteristic of phosphorus deficiency syndrome by the fourth week. Thereafter, serum alkaline phosphatase activity (ALP) decreased and serum P increased in all group II infants. Conversely, serum ALP rose and hypophosphatemia persisted in most group I infants. Group II had a significantly higher serum P at weeks 8 and 12 and a significantly lower ALP at week 12 than group I. Furthermore, group II had a lower incidence of severe radiographic abnormalities than group I at week 12. We confirmed previous observations that VLBW infants fed exclusively human milk require P and Ca supplementation to prevent metabolic bone disease of prematurity.
H Tsukahara; I Mitsuyoshi; T Sakaguchi; H Fukuhara; S Hayashi; K Nakamura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta paediatrica Japonica; Overseas edition     Volume:  31     ISSN:  0374-5600     ISO Abbreviation:  Acta Paediatr Jpn     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-09-15     Completed Date:  1989-09-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370357     Medline TA:  Acta Paediatr Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  58-64     Citation Subset:  IM    
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MeSH Terms
Bone and Bones / metabolism*
Infant Food*
Infant, Low Birth Weight*
Infant, Newborn
Milk, Human*
Minerals / metabolism*
Reg. No./Substance:

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