Document Detail

Improved blood pressure, nitric oxide and asymmetric dimethylarginine are independent after bariatric surgery.
MedLine Citation:
PMID:  23065529     Owner:  NLM     Status:  Publisher    
BACKGROUND: Obesity is associated with hypertension, but the exact mechanism is not fully understood. Bariatric surgery significantly decreases weight and blood pressure (BP). Low plasma nitric oxide (NO) and raised asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO, concentrations are associated with both obesity and hypertension. Correlations between the changes in these parameters were studied after bariatric surgery. METHODS: Weight, BP, plasma ADMA and NO were measured in 29 obese patients (24 female, 5 male) before and six weeks after bariatric surgery. RESULTS: Patients were 39.2 ± 1.2 (mean ± SEM) years old and weighed 126 ± 3 kg. Six weeks after the surgery, patients had lost 10 ± 0.7 kg (P < 0.0001) and mean arterial pressure (MAP) decreased by 11 ± 1.0 mmHg (P < 0.0001). The plasma ADMA concentration decreased by 24 ± 2% from 5 ± 0.4 to 4.0 ± 0.3 μmol/L (P < 0.0001). The plasma total nitrite concentration increased by 15 ± 1% from 51.4 ± 2.6 to 60 ± 3 μmol/L (P < 0.0001). The correlation between the decrease of ADMA and increase of NO subsequent to weight loss was significant (P < 0.0001). However, MAP was not correlated to the changes in ADMA or NO. CONCLUSIONS: After bariatric surgery, beneficial changes in BP, NO and ADMA occur, but our findings suggest that these BP changes are independent of changes in the NO-ADMA axis. Other causes for the changes in BP should therefore be considered.
R Patle; S Dubb; J Alaghband-Zadeh; R A Sherwood; F Tam; A Frankel; C Moniz; M Bueter; R P Vincent; C W le Roux
Related Documents :
15319419 - Chronic intermittent hypoxia enhances cat chemosensory and ventilatory responses to hyp...
8447869 - Protective effects of a prostaglandin oligomer on rats exposed to hypoxia.
10937889 - The brain trauma foundation. the american association of neurological surgeons. the joi...
3987729 - Pulmonary oedema following choking: report of two cases.
603879 - Failure of saralasin acetate, a competitive inhibitor of angiotensin ii, to diminish al...
1600639 - Hypoxic attenuation of brain stem serotonin does not influence sodium-induced hypertens...
8747169 - Evidence for inert gas narcosis mechanisms in the occurrence of psychotic-like episodes...
3943179 - Milrinone versus dobutamine: contribution of altered myocardial mechanics and augmented...
8228209 - Biochemical and neurohormonal responses to the introduction of a lacto-ovovegetarian diet.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-12
Journal Detail:
Title:  Annals of clinical biochemistry     Volume:  -     ISSN:  1758-1001     ISO Abbreviation:  Ann. Clin. Biochem.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0324055     Medline TA:  Ann Clin Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Clinical Biochemistry Department, King's College Hospital NHS Foundation Trust, London SE5 9RS.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Reference intervals for plasma free metanephrines with an age adjustment for normetanephrine for opt...
Next Document:  Novel mutations in the Dubin-Johnson syndrome gene ABCC2/MRP2 and associated biochemical changes.