Document Detail


Improved autonomic neurocardial balance in short-term abstinent alcoholics treated with acamprosate.
MedLine Citation:
PMID:  9872347     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Standardized investigations on resting heart rate variability (HRV) should provide more information on acamprosate's human pharmacodynamic properties because acamprosate interacts with several neurotransmitter systems which are also involved in maintaining autonomic neurocardiac balance. We performed HRV measurements prospectively in 69 healthy controls and 19 chronic alcoholics to prove the hypotheses that: (1) compared to healthy controls, chronic alcoholics show disturbances in neurocardiac vagal function; and (2) in alcoholics, acamprosate treatment (6-8 days) should further decrease parasympathetic activity if acamprosate interacts with central gamma-aminobutyric acidA receptors in vivo. Cardiovagal dysfunction was initially present in 21% of the alcoholics. After treatment. however, their neurocardiac sympathetic-parasympathetic balance improved significantly.
Authors:
M W Agelink; W Lemmer; R Malessa; T Zeit; T Majewski; E Klieser
Related Documents :
7112177 - Social, spatial and political determinants of u.s. abortion rates.
15162847 - Fetal adh2*3, maternal alcohol consumption, and fetal growth.
9291347 - The effects of inadvertent exposure of mefloquine chemoprophylaxis on pregnancy outcome...
6874207 - Drinking habits and death. the yugoslavia cardiovascular disease study.
20456277 - Methaemoglobinaemia risk factors with inhaled nitric oxide therapy in newborn infants.
7205907 - Pericentric inversion (13) with two different recombinants in the same family.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Alcohol and alcoholism (Oxford, Oxfordshire)     Volume:  33     ISSN:  0735-0414     ISO Abbreviation:  Alcohol Alcohol.     Publication Date:    1998 Nov-Dec
Date Detail:
Created Date:  1999-03-22     Completed Date:  1999-03-22     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  8310684     Medline TA:  Alcohol Alcohol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  602-5     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Evangelical Hospital Gelsenkirchen, University of Bochum, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Alcohol Deterrents / therapeutic use*
Alcoholism / drug therapy*
Female
Heart Rate / drug effects*
Humans
Male
Middle Aged
Multivariate Analysis
Taurine / analogs & derivatives*,  therapeutic use
Temperance
Chemical
Reg. No./Substance:
0/Alcohol Deterrents; 107-35-7/Taurine; N4K14YGM3J/acamprosate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Sexual abuse and the subsequent development of alcohol problems.
Next Document:  Presence of plasma endotoxin is correlated with tumour necrosis factor receptor levels and disease a...