Document Detail

Improved autonomic neurocardial balance in short-term abstinent alcoholics treated with acamprosate.
MedLine Citation:
PMID:  9872347     Owner:  NLM     Status:  MEDLINE    
Standardized investigations on resting heart rate variability (HRV) should provide more information on acamprosate's human pharmacodynamic properties because acamprosate interacts with several neurotransmitter systems which are also involved in maintaining autonomic neurocardiac balance. We performed HRV measurements prospectively in 69 healthy controls and 19 chronic alcoholics to prove the hypotheses that: (1) compared to healthy controls, chronic alcoholics show disturbances in neurocardiac vagal function; and (2) in alcoholics, acamprosate treatment (6-8 days) should further decrease parasympathetic activity if acamprosate interacts with central gamma-aminobutyric acidA receptors in vivo. Cardiovagal dysfunction was initially present in 21% of the alcoholics. After treatment. however, their neurocardiac sympathetic-parasympathetic balance improved significantly.
M W Agelink; W Lemmer; R Malessa; T Zeit; T Majewski; E Klieser
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Alcohol and alcoholism (Oxford, Oxfordshire)     Volume:  33     ISSN:  0735-0414     ISO Abbreviation:  Alcohol Alcohol.     Publication Date:    1998 Nov-Dec
Date Detail:
Created Date:  1999-03-22     Completed Date:  1999-03-22     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  8310684     Medline TA:  Alcohol Alcohol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  602-5     Citation Subset:  IM    
Department of Psychiatry, Evangelical Hospital Gelsenkirchen, University of Bochum, Germany.
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MeSH Terms
Alcohol Deterrents / therapeutic use*
Alcoholism / drug therapy*
Heart Rate / drug effects*
Middle Aged
Multivariate Analysis
Taurine / analogs & derivatives*,  therapeutic use
Reg. No./Substance:
0/Alcohol Deterrents; 107-35-7/Taurine; N4K14YGM3J/acamprosate

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