Document Detail

Improved assessment of body cell mass by segmental bioimpedance analysis in malnourished subjects and acromegaly.
MedLine Citation:
PMID:  12706134     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Estimation of body cell mass (BCM) has been regarded valuable for the assessment of malnutrition. AIM: To investigate the value of segmental bioelectrical impedance analysis (BIA) for BCM estimation in malnourished subjects and acromegaly. METHODS: Nineteen controls and 63 patients with either reduced (liver cirrhosis without and with ascites, Cushing's disease) or increased BCM (acromegaly) were included. Whole-body and segmental BIA (separately measuring arm, trunk, leg) at 50 kHz was compared with BCM measured by total-body potassium. Multiple regression analysis was used to develop specific equations for BCM in each subgroup. RESULTS: Compared to whole-body BIA equations, the inclusion of arm resistance improved the specific equation in cirrhotic patients without ascites and in Cushing's disease resulting in excellent prediction of BCM (R(2) = 0.93 and 0.92, respectively; both P<0.001). In acromegaly, inclusion of resistance and reactance of the trunk best described BCM (R(2) = 0.94, P<0.001). In controls and in cirrhotic patients with ascites, segmental impedance parameters did not improve BCM prediction (best values obtained by whole-body measurements: R(2)=0.88 and 0.60; P<0.001 and <0.003, respectively). CONCLUSION: Segmental BIA improves the assessment of BCM in malnourished patients and acromegaly, but not in patients with severe fluid overload.
M Pirlich; T Schütz; J Ockenga; H Biering; H Gerl; B Schmidt; S Ertl; M Plauth; H Lochs
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical nutrition (Edinburgh, Scotland)     Volume:  22     ISSN:  0261-5614     ISO Abbreviation:  Clin Nutr     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-22     Completed Date:  2003-10-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8309603     Medline TA:  Clin Nutr     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  167-74     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Elsevier Science Ltd.
Medizinische Klinik und Poliklinik, Abteilung Gastroenterologie, Universitätsklinikum Charité, Humboldt-Universität zu Berlin, Germany.
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MeSH Terms
Acromegaly / complications,  diagnosis,  physiopathology*
Ascites / complications,  physiopathology
Body Composition*
Body Water / metabolism
Cushing Syndrome / physiopathology
Electric Impedance
Liver Cirrhosis / complications,  physiopathology
Middle Aged
Multivariate Analysis
Nutrition Disorders / diagnosis,  etiology,  physiopathology*
Nutritional Status
Potassium / analysis
Reg. No./Substance:
Erratum In:
Clin Nutr. 2004 Apr;23(2):285-6

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