Document Detail

Improved arteriole-to-venule ratio of retinal vessels resulting from bariatric surgery.
MedLine Citation:
PMID:  22555362     Owner:  NLM     Status:  Publisher    
Obesity causes increased morbidity and mortality from metabolic and cardiovascular disease. We investigated the effect of bariatric surgery on endothelial dysfunction in retinal vessels as a marker of metabolic and cardiovascular risk in patients with obesity WHO III°.Thirty consecutive patients (19/11, w/m) were evaluated by anthropometry, lipid profile, and oral glucose tolerance test before and after bariatric surgery (Mannheim Obesity Study MOS; NCT 00770276). Risk stratification was performed by the presence of metabolic syndrome (MetS) according to ATP-III. Subclinical atherosclerosis was assessed by measurement of intima media thickness (IMT). Flicker light response of retinal vessels was used as measures of endothelial dysfunction (ED). We measured their arteriole-to-venule ratio (AVR) for evaluation of vascular pathology. After a median of 9 months following bariatric surgery, mean weight loss was 39.4 kg (37.3%). Remission of impaired glucose metabolism was achieved in 53.3% of affected patients. Dyslipidemia improved significantly (triglycerides -61.3 mg/dl, p<0.0001, total cholesterol - 28.2 mg/dl, p=0.002 and LDL-cholesterol were reduced -24.5 mg/dl, p=0.008). This resulted in a significant reduction of patients classified for MetS (27 vs. 9, p<0.0001). Adiponectin increased by 2.08 µg/l (p=0.032) and hs-CRP and sICAM decreased (-7.3 mg/l, p<0.0001 and -146.4 ng/ml, p=0.0006). AVR improved significantly (+0.04, p<0.0001), but neither Flicker light response nor IMT changed significantly. Retinal AVR is ameliorated after bariatric intervention. As an increased AVR results from either or both widening retinal arteriolar caliber and narrowing retinal venular caliber, an improvement in small vessel profile is evident 9 months after bariatric surgery.
Alexander Lammert; Till Hasenberg; Caroline Kräupner; Peter Schnülle; Hans-Peter Hammes
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-04
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  -     ISSN:  1930-7381     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Fifth Medical Clinic, and 2. Department of Surgery, Universitätsmedizin Mannheim, University of Heidelberg, Germany.
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