Document Detail

Improved arterial spin labeling after myocardial infarction in mice using cardiac and respiratory gated look-locker imaging with fuzzy C-means clustering.
MedLine Citation:
PMID:  20187175     Owner:  NLM     Status:  MEDLINE    
Experimental myocardial infarction (MI) in mice is an important disease model, in part due to the ability to study genetic manipulations. MRI has been used to assess cardiac structural and functional changes after MI in mice, but changes in myocardial perfusion after acute MI have not previously been examined. Arterial spin labeling noninvasively measures perfusion but is sensitive to respiratory motion and heart rate variability and is difficult to apply after acute MI in mice. To account for these factors, a cardiorespiratory-gated arterial spin labeling sequence using a fuzzy C-means algorithm to retrospectively reconstruct images was developed. Using this method, myocardial perfusion was measured in remote and infarcted regions at 1, 7, 14, and 28 days post-MI. Baseline perfusion was 4.9 +/- 0.5 mL/g min and 1 day post-MI decreased to 0.9 +/- 0.8 mL/g min in infarcted myocardium (P < 0.05 versus baseline) while remaining at 5.2 +/- 0.8 mL/g min in remote myocardium. During the subsequent 28 days, perfusion in the remote zone remained unchanged, while a partial recovery of perfusion in the infarct zone was seen. This technique, when applied to genetically engineered mice, will allow for the investigation of the roles of specific genes in myocardial perfusion during infarct healing.
Moriel H Vandsburger; Robert L Janiczek; Yaqin Xu; Brent A French; Craig H Meyer; Christopher M Kramer; Frederick H Epstein
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  63     ISSN:  1522-2594     ISO Abbreviation:  Magn Reson Med     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-03     Completed Date:  2010-06-09     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  648-57     Citation Subset:  IM    
Copyright Information:
(c) 2010 Wiley-Liss, Inc.
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MeSH Terms
Cardiac-Gated Imaging Techniques / methods*
Fuzzy Logic*
Image Enhancement / methods
Image Interpretation, Computer-Assisted / methods*
Magnetic Resonance Angiography / methods*
Mice, Inbred C57BL
Myocardial Infarction / diagnosis*
Pattern Recognition, Automated / methods*
Reproducibility of Results
Respiratory-Gated Imaging Techniques / methods*
Sensitivity and Specificity
Spin Labels
Grant Support
Reg. No./Substance:
0/Spin Labels

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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