| Improved aortocoronary bypass patency by low-dose aspirin (100 mg daily). Effects on platelet aggregation and thromboxane formation. | |
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MedLine Citation:
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PMID: 6144975 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prevention of aortocoronary bypass occlusion by aspirin (ASA, 1 X 100 mg per day) was studied in a prospective double-blind trial of 83 patients. 60 (72%) were randomly allocated to ASA or placebo starting 24 h after operation. 90% of grafts in the ASA group and 68% in the placebo group were patent at four months. At least one anastomosis was occluded in 62% of the patients on placebo and in 27% of those on aspirin. Ventricular arrhythmias increased after surgery in more patients on placebo (12/18) than in patients on ASA (5/17). Platelet thromboxane formation on collagen tested before operation was significantly higher in patients in whom bypass occlusion developed (occlusion: 40 +/- 19, no occlusion: 25 +/- 13 ng/ml). A 100 mg dose of ASA per day effectively blocked platelet thromboxane formation and thromboxane-supported aggregation on collagen and was safe in the postoperative phase. No side effects were reported throughout the trial. The reduced toxicity with full efficacy favours a low and infrequent dosage of aspirin. |
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Authors:
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R L Lorenz; C V Schacky; M Weber; W Meister; J Kotzur; B Reichardt; K Theisen; P C Weber |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Lancet Volume: 1 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 1984 Jun |
Date Detail:
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Created Date: 1984-07-16 Completed Date: 1984-07-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1261-4 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aspirin
/
administration & dosage,
pharmacology* Blood Platelets / metabolism Clinical Trials as Topic Coronary Artery Bypass* Double-Blind Method Female Graft Survival Humans Male Middle Aged Platelet Aggregation / drug effects* Prospective Studies Random Allocation Thromboxanes / biosynthesis* |
| Chemical | |
Reg. No./Substance:
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0/Thromboxanes; 50-78-2/Aspirin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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