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Improved anemia is associated with favorable long-term clinical outcomes in patients undergoing PCI.
MedLine Citation:
PMID:  22781740     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Anemia is associated with an increased risk of mortality in patients who underwent percutaneous coronary intervention (PCI) in the bare-metal stent era. However, there have been no data concerning the clinical importance of anemia improvement during the follow-up period after discharge from the hospital during the drug-eluting stent era. METHODS AND RESULTS: To assess anemia, the hemoglobin level was measured at the time of index PCI with drug-eluting stents and at the subsequent outpatient visit between 3 and 12 months later. Improvement of anemia was defined by the normalization of the hemoglobin level at the follow-up laboratory examination. We analyzed 4300 patients who were tested for initial and follow-up hemoglobin levels. We compared major adverse cardiac and cerebrovascular events (MACCE) between the normal group and the anemia group and between the improved anemia group and the sustained anemia group. The median follow-up period was 25.4 months. There was poorer clinical outcome in the anemia group than in the normal group in terms of MACCE (adjusted hazard ratio 1.479, 95% confidence interval 1.025-2.134, P=0.037). Furthermore, the sustained anemia group showed poorer MACCE than did the improved anemia group (hazard ratio 3.558, 95% confidence interval 2.285-5.539, P<0.0001). On the basis of the multivariate Cox hazard regression model and propensity-score matching, the overall findings were consistent between sustained and improved anemia groups. CONCLUSION: The follow-up of hemoglobin level is important, and improvement of anemia is associated with favorable long-term clinical outcomes.
Authors:
Tae-Hoon Kim; Yoon-Seok Koh; Kiyuk Chang; Suk-Min Seo; Chan-Joon Kim; Hun-Jun Park; Pum-Joon Kim; Sung Ho Her; Dong-Bin Kim; Jong-Min Lee; Chul-Soo Park; Hee-Yeol Kim; Ki-Dong Yoo; Doo Soo Jeon; Jae Hong Park; Wook-Sung Chung; Ki-Bae Seung;
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-6
Journal Detail:
Title:  Coronary artery disease     Volume:  -     ISSN:  1473-5830     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
aCardiovascular Center and Cardiology Division, Seoul St Mary's Hospital and College of Medicine bCardiovascular Center and Division of Cardiology, Yeouido St Mary's Hospital cCardiovascular Center and Division of Cardiology, St Paul's Hospital, The Catholic University of Korea dDepartment of Internal Medicine, Division of Cardiology, Kangnam General Hospital, Seoul eCardiovascular Center and Division of Cardiology, Uijeongbu St Mary's Hospital, The Catholic University of Korea, Uijeongbu fCardiovascular Center and Division of Cardiology, Daejeon St Mary's Hospital, The Catholic University of Korea, Daejeon gCardiovascular Center and Division of Cardiology, Bucheon St Mary's Hospital, The Catholic University of Korea, Bucheon hCardiovascular Center and Division of Cardiology, St Vincent's Hospital, The Catholic University of Korea, Suwon iCardiovascular Center and Division of Cardiology, Incheon St Mary's Hospital, The Catholic University of Korea, Incheon, Republic of Korea.
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