| Improved synthesis of (E)-12-nitrooctadec-12-enoic acid, a potent PPARγ activator. Development of a "buffer-free" enzymatic method for hydrolysis of methyl esters. | |
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MedLine Citation:
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PMID: 21062087 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Endogenous nitro-fatty acids, acting as partial agonist of PPARγ, are able to lower the insulin and glucose levels without the side effects associated with common antidiabetic drugs. (E)-12-Nitrooctadec-12-enoic acid, a potent activator of this peroxisome receptor, was synthesized in a very efficient sequence via a Henry-retro-Claisen ring fragmentation, followed by a novel enzymatic cleavage of methyl esters. The latter method was then applied in the last step of the synthesis of a few labile natural products, such as prostaglandins, isoprostanes, and phytoprostanes. |
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Authors:
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Giuseppe Zanoni; Matteo Valli; Lyamin Bendjeddou; Alessio Porta; Paolo Bruno; Giovanni Vidari |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-11-09 |
Journal Detail:
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Title: The Journal of organic chemistry Volume: 75 ISSN: 1520-6904 ISO Abbreviation: J. Org. Chem. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985193R Medline TA: J Org Chem Country: United States |
Other Details:
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Languages: eng Pagination: 8311-4 Citation Subset: IM |
Affiliation:
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Department of Organic Chemistry, University of Pavia, Pavia, Italy. gz@unipv.it |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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