Document Detail

Improved Pressure-Frequency Sensing Subxiphoid Pericardial Access System: Performance Characteristics during in vivo Testing.
MedLine Citation:
PMID:  21147589     Owner:  NLM     Status:  Publisher    
We have designed, synthesized and tested an improved version of our original subxiphoid access system intended to facilitate epicardial electrophysiology. The new version of the system incorporates a precision fiber-optic pressure sensor and a novel signal analysis algorithm for identifying pressure-frequency signatures which, in the clinical setting, may allow for safer access to the pericardial space. Following in vivo studies on 10 adult canine models, we analyzed 215 pressure-frequency measurements made at the distal tip of the access needle, of which 98 were from non-pericardial, 112 were from pericardial and 5 were from ventricular locations. The needle locations as identified by the algorithm were significantly different from each other (p < 0.01), and the algorithm had improved performance when compared to a standard FFT analysis of the same data. Moreover, the structure of the algorithm can potentially overcome the time lags intrinsic to FFT analysis, such that the needles location can be determined in near-real time. Hydrodynamic pressure-frequency measurements made during traversal of the pericardial membrane revealed a distinct change in signal structure between the pericardial and non-pericardial anatomy. We present and discuss the design principles, details of construction and performance characteristics of this system.
J Tucker-Schwartz; G Gillies; S Mahapatra
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-10
Journal Detail:
Title:  IEEE transactions on bio-medical engineering     Volume:  -     ISSN:  1558-2531     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0012737     Medline TA:  IEEE Trans Biomed Eng     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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