Document Detail


Improved motion perception and impaired spatial suppression following disruption of cortical area MT/V5.
MedLine Citation:
PMID:  21273412     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
As stimulus size increases, motion direction of high-contrast patterns becomes increasingly harder to perceive. This counterintuitive behavioral result, termed "spatial suppression," is hypothesized to reflect center-surround antagonism-a receptive field property ubiquitous in sensory systems. Prior research proposed that spatial suppression of motion signals is a direct correlate of center-surround antagonism within cortical area MT. Here, we investigated whether human MT/V5 is indeed causally involved in spatial suppression of motion signals. The key assumption is that a disruption of neural mechanisms that play a critical role in spatial suppression could allow these normally suppressed motion signals to reach perceptual awareness. Thus, our hypothesis was that a disruption of MT/V5 should weaken spatial suppression and, consequently, improve motion perception of large, moving patterns. To disrupt MT/V5, we used offline 1 Hz transcranial magnetic stimulation (TMS)-a method that temporarily attenuates normal functioning of the targeted cortex. Early visual areas were also targeted as a control site. The results supported our hypotheses and showed that disruption of MT/V5 improved motion discrimination of large, moving stimuli, presumably by weakening surround suppression strength. This effect was specific to MT/V5 stimulation and contralaterally presented stimuli. Evidently, the critical neural constraints limiting motion perception of large, high-contrast stimuli involve MT/V5. Additionally, our findings mimic spatial suppression deficits that are observed in several patient populations and implicate impaired MT/V5 processes as likely neural correlates for the reported perceptual abnormalities in the elderly, patients with schizophrenia and those with a history of depression.
Authors:
Duje Tadin; Juha Silvanto; Alvaro Pascual-Leone; Lorella Battelli
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  31     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-28     Completed Date:  2011-03-30     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1279-83     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Humans
Magnetic Resonance Imaging
Motion Perception*
Perceptual Disorders / physiopathology,  psychology
Space Perception*
Transcranial Magnetic Stimulation
Visual Cortex / physiopathology*
Young Adult
Grant Support
ID/Acronym/Agency:
K24 RR018875/RR/NCRR NIH HHS; R01 EY019295/EY/NEI NIH HHS; R01 EY019295/EY/NEI NIH HHS; R01 EY019295-01A2/EY/NEI NIH HHS; R01 EY019295-02/EY/NEI NIH HHS; R01 EY12091/EY/NEI NIH HHS; R01-DC006842/DC/NIDCD NIH HHS; UL1 RR025758/RR/NCRR NIH HHS
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