| Improved language in a chronic nonfluent aphasia patient after treatment with CPAP and TMS. | |
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MedLine Citation:
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PMID: 20299861 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To present pretreatment and post-treatment language data for a nonfluent aphasia patient who received 2 treatment modalities: (1) continuous positive airway pressure (CPAP) for his sleep apnea, starting 1-year poststroke; and (2) repetitive transcranial magnetic brain stimulation (TMS), starting 2 years poststroke. BACKGROUND: Language data were acquired beyond the spontaneous recovery period of 3 to 6 months poststroke onset. CPAP restores adequate oxygen flow throughout all stages of sleep, and may improve cognition. A series of slow, 1 Hz repetitive TMS treatments to suppress a posterior portion of right pars triangularis has been shown to improve phrase length and naming in chronic nonfluent aphasia. METHOD: The Boston Diagnostic Aphasia Examination and Boston Naming Test were administered pre-CPAP, and after 2 to 5 months of CPAP. These same tests were administered pre-TMS, and at 3 and 6 months post-TMS, and again 2.4 years later. RESULTS: Post-CPAP testing showed increased Phrase Length, Auditory Comprehension, and naming Animals and Tools/Implements (Boston Diagnostic Aphasia Examination). Testing at 3 and 6 months post-TMS showed significant increase in Phrase Length, Auditory Comprehension, and Boston Naming Test compared with pre-TMS. These gains were retained at 2.4 years post-TMS. CPAP use continued throughout. CONCLUSIONS: Physiologic treatment interventions may promote language recovery in chronic aphasia. |
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Authors:
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Margaret A Naeser; Paula I Martin; Kristine Lundgren; Reva Klein; Jerome Kaplan; Ethan Treglia; Michael Ho; Marjorie Nicholas; Miguel Alonso; Alvaro Pascual-Leone |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology Volume: 23 ISSN: 1543-3641 ISO Abbreviation: Cogn Behav Neurol Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-19 Completed Date: 2010-06-23 Revised Date: 2012-02-15 |
Medline Journal Info:
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Nlm Unique ID: 101167278 Medline TA: Cogn Behav Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 29-38 Citation Subset: IM |
Affiliation:
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Department of Neurology, Harold Goodglass Boston University Aphasia Research Center, Boston University School of Medicine and the Veterans Affairs Boston Healthcare System, Boston, MA 02130, USA. mnaeser@bu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aphasia, Broca
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diagnosis,
therapy* Chronic Disease Continuous Positive Airway Pressure / methods* Humans Language* Male Middle Aged Neuropsychological Tests Severity of Illness Index Transcranial Magnetic Stimulation / methods* Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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K24 RR018875-05/RR/NCRR NIH HHS; M01 RR001032-316089/RR/NCRR NIH HHS; P30 DC005207-08/DC/NIDCD NIH HHS; R01 DC005672-05/DC/NIDCD NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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