Document Detail


Improved Ion Mobility Resolving Power with Increased Buffer Gas Pressure.
MedLine Citation:
PMID:  22591048     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Security and military applications of analytical techniques demand a small, rugged, reliable instrument that has traditionally been served well by atmospheric pressure ion mobility spectrometry (IMS) systems. Modern threats stipulate these instruments must reliably operate in increasingly complex environments. Previous work has demonstrated that increasing the pressure of an IMS drift tube has the potential to increase resolving power of IMS, but operation at low temperatures resulted in a leveling of the measured resolving power as a function of pressure. By creating a novel aperture grid/faraday plate design, a High-Pressure IMS (HPIMS) system has been created that maintains a resolving power efficiency of 80% regardless of the pressure applied to the cell. This allows previously-unattainable resolving powers to be achieved utilizing a small (10.7 cm) IMS cell. Using high pressure, a stand-alone IMS cell of 10.7 cm length has demonstrated a resolving power of 102 when operated at 2.5 atm. An increase in peak-to-peak resolution was also noted as pressure increased. Finally, the slope of the resulting inverse mobility/pressure curve for a single analyte has been shown to be proportional to the collision-cross-section of the analyte of interest, providing a novel method for the calculation of collision-cross-section of target ions from HPIMS data.
Authors:
Eric James Davis; Kristopher F Grows; William F Siems; Herbert H Hill Jr
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-15
Journal Detail:
Title:  Analytical chemistry     Volume:  -     ISSN:  1520-6882     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370536     Medline TA:  Anal Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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