| Improved High-Fat Diet-Induced Glucose Intolerance by an Oral Administration of Phytosphingosine. | |
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MedLine Citation:
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PMID: 23291756 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We have previously reported that phytoceramide and phytosphingosine (PHS) stimulated the transcriptional activity of peroxisome proliferator-activated receptor γ (PPARγ) in cells. PPARγ is a therapeutic target for type 2 diabetes. We found in this study that an oral administration of PHS improved diet-induced glucose intolerance in mice. Since PHS is highly expressed in yeast, PHS in fermented foods may improve diabetes. |
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Authors:
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Itsuo Murakami; Susumu Mitsutake; Naoyuki Kobayashi; Junko Matsuda; Akemi Suzuki; Tatsuro Shigyo; Yasuyuki Igarashi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-07 |
Journal Detail:
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Title: Bioscience, biotechnology, and biochemistry Volume: - ISSN: 1347-6947 ISO Abbreviation: Biosci. Biotechnol. Biochem. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205717 Medline TA: Biosci Biotechnol Biochem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Laboratory of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life Sciences, Hokkaido University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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