| Improved DNA vaccination by skin-targeted delivery using dry-coated densely-packed microprojection arrays. | |
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MedLine Citation:
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PMID: 20850487 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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HSV-2-gD2 DNA vaccine was precisely delivered to immunologically sensitive regions of the skin epithelia using dry-coated microprojection arrays. These arrays delivered a vaccine payload to the epidermis and the upper dermis of mouse skin. Immunomicroscopy results showed that, in 43 ± 5% of microprojection delivery sites, the DNA vaccine was delivered to contact with professional antigen presenting cells in the epidermal layer. Associated with this efficient delivery of the vaccine into the vicinity of the professional antigen presenting cells, we achieved superior antibody responses and statistically equal protection rate against an HSV-2 virus challenge, when compared with the mice immunized with intramuscular injection using needle and syringe, but with less than 1/10th of the delivered antigen. |
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Authors:
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Xianfeng Chen; Angela Shaulov Kask; Michael L Crichton; Celia McNeilly; Sally Yukiko; Lichun Dong; Joshua O Marshak; Courtney Jarrahian; Germain J P Fernando; Dexiang Chen; David M Koelle; Mark A F Kendall |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-17 |
Journal Detail:
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Title: Journal of controlled release : official journal of the Controlled Release Society Volume: 148 ISSN: 1873-4995 ISO Abbreviation: J Control Release Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607908 Medline TA: J Control Release Country: Netherlands |
Other Details:
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Languages: eng Pagination: 327-33 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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The University of Queensland, Delivery of Drugs and Genes Group, Australian Institute for Bioengineering and Nanotechnology, Brisbane, Queensland 4072, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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