| Improved automated screening of diabetic retinopathy. | |
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MedLine Citation:
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PMID: 21865671 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To assess a two-step automated system (RetmarkerSR) that analyzes retinal photographs to detect diabetic retinopathy for the purpose of reducing the burden of manual grading. METHODS: Anonymous images from 5,386 patients screened in 2007 were obtained from a nonmydriatic diabetic retinopathy screening program in Portugal and graded by an experienced ophthalmologist. RetmarkerSR earmarked microaneurysms, generating two outputs: 'disease' or 'no disease'. A second-step analysis, based on coregistration, combining two visits, was subsequently performed in 289 patients who underwent repeated examinations in 2008. The study was extended by analyzing all referrals considered urgent by the ophthalmologist from 2001 to 2007. Results were compared with those obtained by manual grading. RESULTS: The RetmarkerSR classified in a first-step analysis 2,560 patients (47.5%) as having 'no disease' and 2,826 patients (52.5%) as having 'disease', thus requiring manual grading. RetmarkerSR detected all eyes considered urgent referrals. The two-step analysis further reduced the number of false-positive results by 26.3%, indicating an overall sensitivity of 95.8% and a specificity of 63.2%. CONCLUSION: Automated grading of diabetic retinopathy may safely reduce the burden of grading patients in diabetic retinopathy screening programs. The novel two-step automated analysis system offers improved sensitivity and specificity over published automated analysis systems. |
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Authors:
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Carlos M Oliveira; Luis M Cristóvão; Maria Luisa Ribeiro; José R Faria Abreu |
Publication Detail:
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Type: Journal Article Date: 2011-08-25 |
Journal Detail:
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Title: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde Volume: 226 ISSN: 1423-0267 ISO Abbreviation: Ophthalmologica Publication Date: 2011 |
Date Detail:
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Created Date: 2011-11-01 Completed Date: 2012-01-06 Revised Date: 2012-04-26 |
Medline Journal Info:
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Nlm Unique ID: 0054655 Medline TA: Ophthalmologica Country: Switzerland |
Other Details:
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Languages: eng Pagination: 191-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
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Critical Health, University Hospital of Coimbra, Coimbra, Portugal. caoliveira@critical-health.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Diabetic Retinopathy / classification, diagnosis* False Positive Reactions Fluorescein Angiography / methods* Humans Image Processing, Computer-Assisted / methods* Predictive Value of Tests ROC Curve Reproducibility of Results Sensitivity and Specificity |
| Comments/Corrections | |
Comment In:
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Ophthalmologica. 2012;227(3):173; author reply 174
[PMID:
22212182
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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