| Improved 3-D-echocardiographic endocardial border delineation using the contrast agent FS069 (Optison) transesophageal studies in a porcine model. | |
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MedLine Citation:
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PMID: 11597358 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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3-D echocardiography has the potential for quantitative assessment of regional wall motion. However, the 3-D procedures used to date do not provide the same spatial and temporal resolution as 2-D echocardiography, which results in problems with border delineation of the endocardium. There are, as yet, few studies testing if the use of contrast agent can improve endocardial definition in the 3-D data set. FS069 (Optison) was used for the first time for this purpose in the present study. A total of 12 mechanically-ventilated pigs were examined by transesophageal 3-D echocardiography, 1. using fundamental imaging and 2. following left-atrial injection of FS069 (Optison). The left ventricle was analyzed using an 18-segment model. Score with the value 0 (not visible), 1 (moderately visible) and 2 (well defined) were used to rate endocardial definition. All segments were assessed both end-diastolic and end-systolic. Various LV regions were examined by grouping segments (anterior/lateral/inferior and basal/mid-ventricular/apical). Using the contrast agent, the proportion of nonvisible segments fell diastolic from 40 (18.5%) to 15 (6.9%), and systolic from 26 (12.0%) to 11 (5.1%). The proportion of well defined segments increased diastolic from 62 (28.7%) to 108 (50%) and systolic from 73 (33.8%) to 123 (56.9%). The mean visibility score increased diastolic from 1.10 +/- 0.68 to 1.43 +/- 0.62 (p < 0.001), systolic from 1.22 +/- 0.64 to 1.52 +/- 0.59 (p < 0.001). The benefit was greatest in regions where the visibility score was lowest without contrast: in the area of the lateral wall and systolic near the apex. In conclusion, the use of FS069 (Optison) results in significantly better endocardial delineation in the 3-D data set. This could be important in future for the 3-D echocardiographic assessment of regional wall motion. |
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Authors:
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M Handke; D M Schäfer; G Heinrichs; E Magosaki; G Lutter; P Dern; C Bode; A Geibel |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Ultrasound in medicine & biology Volume: 27 ISSN: 0301-5629 ISO Abbreviation: Ultrasound Med Biol Publication Date: 2001 Sep |
Date Detail:
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Created Date: 2001-10-12 Completed Date: 2001-12-07 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0410553 Medline TA: Ultrasound Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 1185-90 Citation Subset: IM |
Affiliation:
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Department of Cardiology and Angiology, Albert Ludwigs University, Freiburg, Germany. handke@mm31.ukl.uni-freiburg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Albumins
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diagnostic use* Animals Contrast Media / pharmacology* Diastole / physiology Disease Models, Animal Echocardiography, Three-Dimensional / methods* Echocardiography, Transesophageal / methods* Endocardium / physiopathology*, ultrasonography* Fluorocarbons / diagnostic use* Image Processing, Computer-Assisted Reproducibility of Results Respiration, Artificial Swine* Systole / physiology Ventricular Dysfunction, Left / physiopathology*, ultrasonography* |
| Chemical | |
Reg. No./Substance:
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0/Albumins; 0/Contrast Media; 0/FS 069; 0/Fluorocarbons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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