Document Detail

Improved 3-D-echocardiographic endocardial border delineation using the contrast agent FS069 (Optison) transesophageal studies in a porcine model.
MedLine Citation:
PMID:  11597358     Owner:  NLM     Status:  MEDLINE    
3-D echocardiography has the potential for quantitative assessment of regional wall motion. However, the 3-D procedures used to date do not provide the same spatial and temporal resolution as 2-D echocardiography, which results in problems with border delineation of the endocardium. There are, as yet, few studies testing if the use of contrast agent can improve endocardial definition in the 3-D data set. FS069 (Optison) was used for the first time for this purpose in the present study. A total of 12 mechanically-ventilated pigs were examined by transesophageal 3-D echocardiography, 1. using fundamental imaging and 2. following left-atrial injection of FS069 (Optison). The left ventricle was analyzed using an 18-segment model. Score with the value 0 (not visible), 1 (moderately visible) and 2 (well defined) were used to rate endocardial definition. All segments were assessed both end-diastolic and end-systolic. Various LV regions were examined by grouping segments (anterior/lateral/inferior and basal/mid-ventricular/apical). Using the contrast agent, the proportion of nonvisible segments fell diastolic from 40 (18.5%) to 15 (6.9%), and systolic from 26 (12.0%) to 11 (5.1%). The proportion of well defined segments increased diastolic from 62 (28.7%) to 108 (50%) and systolic from 73 (33.8%) to 123 (56.9%). The mean visibility score increased diastolic from 1.10 +/- 0.68 to 1.43 +/- 0.62 (p < 0.001), systolic from 1.22 +/- 0.64 to 1.52 +/- 0.59 (p < 0.001). The benefit was greatest in regions where the visibility score was lowest without contrast: in the area of the lateral wall and systolic near the apex. In conclusion, the use of FS069 (Optison) results in significantly better endocardial delineation in the 3-D data set. This could be important in future for the 3-D echocardiographic assessment of regional wall motion.
M Handke; D M Schäfer; G Heinrichs; E Magosaki; G Lutter; P Dern; C Bode; A Geibel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  27     ISSN:  0301-5629     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-10-12     Completed Date:  2001-12-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1185-90     Citation Subset:  IM    
Department of Cardiology and Angiology, Albert Ludwigs University, Freiburg, Germany.
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MeSH Terms
Albumins / diagnostic use*
Contrast Media / pharmacology*
Diastole / physiology
Disease Models, Animal
Echocardiography, Three-Dimensional / methods*
Echocardiography, Transesophageal / methods*
Endocardium / physiopathology*,  ultrasonography*
Fluorocarbons / diagnostic use*
Image Processing, Computer-Assisted
Reproducibility of Results
Respiration, Artificial
Systole / physiology
Ventricular Dysfunction, Left / physiopathology*,  ultrasonography*
Reg. No./Substance:
0/Albumins; 0/Contrast Media; 0/FS 069; 0/Fluorocarbons

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