Document Detail

Imprinting: perinatal exposures cause the development of diseases during the adult age.
MedLine Citation:
PMID:  10735177     Owner:  NLM     Status:  MEDLINE    
Since the early reports linking the development of clear cell cervicovaginal adenocarcinoma in young women with diethylstilbestrol treatment of their mothers during pregnancy, it became clear that perinatal exposure to several substances may induce irreversible alterations, that can be detected later in life. Current evidence suggests that these substances induce, by the mechanism of imprinting, alterations of the differentiation of several cell-types, resulting in the development of disease during the adult age. The most known delayed effects to prenatal exposure to agents displaying hormone action, pollutants, food additives and natural food components, substances of abuse and stress by the mechanism of imprinting are described. Among them, estrogens, androgens, progestins, lead, benzopyrenes, ozone, dioxins, DDT, DDE, methoxychlor, chlordecone, parathion, malathion, polychlorobiphenyls, pyrethroids, paraquat, food additives, normal food constituents, tetrahydrocannabinol, cocaine and opiates. It is concluded that perinatal exposure to several agents causes irreversible changes that determine health conditions during adulthood. Several diseases developing during adulthood probably were determined during early stages of life, under the effect of exposure or preferential mother's diet during pregnancy. Regulations to avoid these early exposures may contribute to an important improvement of health conditions of humankind.
A N Tchernitchin; N N Tchernitchin; M A Mena; C Unda; J Soto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Acta biologica Hungarica     Volume:  50     ISSN:  0236-5383     ISO Abbreviation:  Acta. Biol. Hung.     Publication Date:  1999  
Date Detail:
Created Date:  2000-05-24     Completed Date:  2000-05-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8404358     Medline TA:  Acta Biol Hung     Country:  HUNGARY    
Other Details:
Languages:  eng     Pagination:  425-40     Citation Subset:  IM    
Laboratory of Experimental Endocrinology and Environmental Pathology LEEPA, University of Chile, Medical School, Santiago.
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MeSH Terms
Environmental Pollutants / adverse effects
Food Additives / adverse effects
Gonadal Steroid Hormones / adverse effects
Prenatal Exposure Delayed Effects*
Stress, Physiological / complications
Substance-Related Disorders / complications
Reg. No./Substance:
0/Environmental Pollutants; 0/Food Additives; 0/Gonadal Steroid Hormones

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