Document Detail


ImprimatinC1, a novel plant immune-priming compound, functions as a partial agonist of salicylic acid.
MedLine Citation:
PMID:  23050089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plant activators are agrochemicals that protect crops from pathogens. They confer durable resistance to a broad range of diseases by activating intrinsic immune mechanisms in plants. To obtain leads regarding useful compounds, we have screened a chemical library using an established method that allows selective identification of immune-priming compounds. Here, we report the characterisation of one of the isolated chemicals, imprimatinC1, and its structural derivative imprimatinC2. ImprimatinC1 functions as a weak analogue of salicylic acid (SA) and activates the expression of defence-related genes. However, it lacks antagonistic activity toward jasmonic acid. Structure-activity relationship analysis suggests that imprimatinC1 and C2 can be metabolised to 4-chlorobenzoic acid and 3,4-chlorobenzoic acid, respectively, to function in Arabidopsis. We also found that imprimatinC1 and C2 and their potential functional metabolites acted as partial agonists of SA. Thus, imprimatinC compounds could be useful tools for dissecting SA-dependent signal transduction pathways.
Authors:
Yoshiteru Noutoshi; Yusuke Jikumaru; Yuji Kamiya; Ken Shirasu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-04
Journal Detail:
Title:  Scientific reports     Volume:  2     ISSN:  2045-2322     ISO Abbreviation:  Sci Rep     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-10     Completed Date:  2013-03-05     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101563288     Medline TA:  Sci Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  705     Citation Subset:  IM    
Affiliation:
Research Core for Interdisciplinary Sciences (RCIS), Okayama University, Kita-ku, Okayama, Japan. noutoshi@cc.okayama-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Arabidopsis / drug effects,  genetics,  immunology*
Arabidopsis Proteins / genetics,  metabolism
Biotransformation
Chlorobenzoates / chemistry,  metabolism,  pharmacology*
Cyclopentanes / metabolism
Gene Expression Regulation, Plant / drug effects
Immunologic Factors / chemistry,  metabolism,  pharmacology*
Oxylipins / metabolism
Plant Growth Regulators / chemistry,  metabolism,  pharmacology*
Plant Immunity / drug effects*
Pyrrolidinones / chemistry,  metabolism,  pharmacology*
Salicylic Acid / agonists*,  metabolism
Signal Transduction / drug effects
Small Molecule Libraries / chemistry,  metabolism,  pharmacology*
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Arabidopsis Proteins; 0/Chlorobenzoates; 0/Cyclopentanes; 0/Immunologic Factors; 0/Oxylipins; 0/Plant Growth Regulators; 0/Pyrrolidinones; 0/Small Molecule Libraries; 0/imprimatinC1; 0/imprimatinC2; 51-44-5/3,4-dichlorobenzoic acid; 69-72-7/Salicylic Acid; 6RI5N05OWW/jasmonic acid; IC7888DF4L/4-chlorobenzoic acid
Comments/Corrections

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