Document Detail


Importin 13 regulates neurotransmitter release at the Drosophila neuromuscular junction.
MedLine Citation:
PMID:  19403829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In an unbiased genetic screen designed to isolate mutations that affect synaptic transmission, we have isolated homozygous lethal mutations in Drosophila importin 13 (imp13). Imp13 is expressed in and around nuclei of both neurons and muscles. At the larval neuromuscular junction (NMJ), imp13 affects muscle growth and formation of the subsynaptic reticulum without influencing any presynaptic structural features. In the absence of imp13, the probability of release of neurotransmitter and quantal content is increased, yet the abundance of the postsynaptic receptors and the amplitude of miniature excitatory junctional potentials are not affected. Interestingly, imp13 is required in the muscles to control presynaptic release. Thus, imp13 is a novel factor that affects neurotransmitter release at the fly NMJ. Its role in the context of synaptic homeostasis is discussed.
Authors:
Nikolaos Giagtzoglou; Yong Qi Lin; Claire Haueter; Hugo J Bellen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  29     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-30     Completed Date:  2009-06-03     Revised Date:  2014-05-28    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5628-39     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Drosophila Proteins / genetics,  physiology*
Drosophila melanogaster
Karyopherins / genetics,  physiology*
Larva / genetics,  physiology
Mutation
Neuromuscular Junction / genetics,  secretion*,  ultrastructure
Neurotransmitter Agents / genetics,  secretion*
Grant Support
ID/Acronym/Agency:
P30 HD024064/HD/NICHD NIH HHS; //Howard Hughes Medical Institute; //Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
0/Drosophila Proteins; 0/Karyopherins; 0/Neurotransmitter Agents; 0/importin 13 protein, Drosophila; 0/importin 13, human
Comments/Corrections

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