| Imported Acquired Immunodeficiency Syndrome-Related Histoplasmosis in Metropolitan France: A Comparison of Pre-Highly Active Anti-Retroviral Therapy and Highly Active Anti-Retroviral Therapy Eras. | |
| | |
MedLine Citation:
|
PMID: 22049053 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Abstract. Histoplasma capsulatum var. capsulatum infection is rare outside disease-endemic areas. Clinical presentation and outcome of acquired immunodeficiency syndrome-related histoplasmosis are unknown in non-endemic areas with wide access to highly active anti-retroviral therapy (HAART). Retrospective analysis of cases recorded at the French National Reference Center for Mycoses and Antifungals during two decades: pre-HAART (1985-1994) and HAART (1997-2006). Clinical features and outcome of all adults with proven acquired immunodeficiency syndrome-related histoplasmosis were compared between the two periods. One hundred four patients were included (40 during the pre-HAART era and 64 during the HAART era). Diagnosis was established a mean of 62 days after onset of symptoms. One-year overall mortality rates decreased from 53% (pre-HAART era) to 22% (HAART era). Diagnosis during the pre-HAART era and an older age were the only independent factors associated with death. Histoplasmosis is a rare invasive fungal infection outside disease-endemic areas. Its prognosis improved significantly during the HAART era. |
| | |
Authors:
|
Vincent Peigne; Françoise Dromer; Caroline Elie; Olivier Lidove; Olivier Lortholary |
Related Documents
:
|
21103193 - Concurrence of stevens-johnson syndrome and bilateral parotitis after minocycline therapy. 6887273 - Retroperitoneal abscess. |
Publication Detail:
|
Type: JOURNAL ARTICLE |
Journal Detail:
|
Title: The American journal of tropical medicine and hygiene Volume: 85 ISSN: 1476-1645 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-3 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370507 Medline TA: Am J Trop Med Hyg Country: - |
Other Details:
|
Languages: ENG Pagination: 934-941 Citation Subset: - |
Affiliation:
|
Institut Pasteur, Unité de Mycologie Moléculaire, Centre National de Référence Mycologie et Antifongiques, Paris, France; Centre National de la Recherche Scientifique Unité de Raccordement des Abonnés 3012, Paris, France; Département de Biostatistiques, Hopital Necker-Enfants Malades, Paris, France; Service de Médecine Interne, Centre Hospitalier Universitaire Bichat, Paris, France; Université Paris Descartes, Hopital Necker-Enfants Malades, Centre d'Infectiologie Necker Pasteur, Paris, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Molecular Detection of Rickettsia felis, Bartonella henselae, and B. clarridgeiae in Fleas from Dome...
Next Document: Validation of probability equation and decision tree in predicting subsequent dengue hemorrhagic Fev...