Document Detail


Important aspects regarding the role of microorganisms in bisphosphonate-related osteonecrosis of the jaws.
MedLine Citation:
PMID:  24859766     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is an important side effect of bisphosphonates, whose etiopathogenesis has not been completely elucidated. Theories pointing to bone turnover and angiogenesis inhibition, as well as effects on epithelial cells of oral mucosa and the role of microorganisms have been reported. Nevertheless, the true contribution of each one of these factors to BRONJ is unknown. We present here a literature review focusing on important aspects regarding the role of microorganisms in BRONJ development. Knowledge about specific microbiota and its role in the etiopathogenesis of this disease can help the optimisation of preventive and therapeutic interventions in patients with or at-risk for BRONJ.
Authors:
Renata Chiapinotto Boff; Fernanda Gonçalves Salum; Maria Antonia Figueiredo; Karen Cherubini
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Publication Detail:
Type:  REVIEW     Date:  2014-5-10
Journal Detail:
Title:  Archives of oral biology     Volume:  59     ISSN:  1879-1506     ISO Abbreviation:  Arch. Oral Biol.     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0116711     Medline TA:  Arch Oral Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  790-799     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ltd. All rights reserved.
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